Results 101 to 110 of about 44,168 (193)

Effects of dietary D-mannose supplementation on growth performance, intestinal digestive capacity, gut microbiota, and ammonia tolerance of largemouth bass Micropterus salmoides

Aquaculture Reports
To investigate the effects of D-mannose on the growth performance, intestinal digestion capacity, intestinal microbiota composition, and ammonia tolerance of largemouth bass, experiments were conducted using largemouth bass fry with an average body ...
Changyi Sun, Muzi Zhang, Dexiang Feng, Shidong Wang, Ming Li   +4 more
doaj   +1 more source

Hypoxia inhibits the induction of argininosuccinate synthetase by endotoxin in lung endothelial cells

, 1997
Pulmonary artery endothelial cells (PAEC) possess a two-step pathway for synthesizing L-arginine from L-citrulline. The first and rate-limiting step is catalyzed by argininosuccinate synthetase (AS).
E. R. Block, Y. Su
core   +1 more source

Discrimination and Identification of Urea-degrading Bacteria in the Fermented Grains of Chinese Nong-xiang Baijiu

Shipin gongye ke-ji
Urea was the main precursor substance of the carcinogenic ethyl carbamate in the production of Baijiu. In this study, urea-degrading microbiota was revealed in the fermented grains from different fermentation cellars of the same brewing enterprise, by ...
Jiahui WANG, Yanqing WANG, Xiaohan LI, Jingyi BIAN, Fei XIE, Jian ZHOU, Guiqiang HE   +6 more
doaj   +1 more source

Urea cycle.

, 2016
In the urea cycle the “toxin” ammonium (NH4+) is converted to non-toxic urea by five consecutive enzymatic reactions in the liver. In hepatocytes, the rate-limiting, ATP-dependent enzyme carbamoyl phosphate synthetase 1 (CPS1), which is allosterically ...
Matthias Gautschi (2608306), Tamar Stricker (2608312), Adrian Keogh (174242), Johannes Häberle (719209), Renata C. Gallagher (2608315), Alexander Laemmle (174189), Jean-Marc Nuoffer (334268), Matthias R. Baumgartner (2608309)   +7 more
core   +1 more source

Expansion Phase 1 Study of Pegargiminase Plus Pemetrexed and Cisplatin in Patients With Argininosuccinate Synthetase 1-Deficient Mesothelioma: Safety, Efficacy, and Resistance Mechanisms. [PDF]

JTO Clin Res Rep, 2020
Szlosarek PW, Phillips MM, Pavlyk I, Steele J, Shamash J, Spicer J, Kumar S, Pacey S, Feng X, Johnston A, Bomalaski J, Moir G, Lau K, Ellis S, Sheaff M.   +14 more
europepmc   +1 more source

Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. [PDF]

Theranostics, 2020
Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR.   +17 more
europepmc   +1 more source

Expression, Regulation and Function of Argininosuccinate Synthetase 1 in Mouse Uterus During Peri-implantation Period

, 2012
精氨酸琥珀酸合成酶（Argininosuccinatesynthetase1，Ass1）能够催化瓜氨酸（L-Citrulline）和天冬氨酸（L-Aspartate）形成精氨琥珀酸，然后在精氨琥珀酸裂解酶（Argininosuccinatelyase，Asl）的作用下，生成精氨酸（L-Arginine）和延胡索酸。由于Asl的表达量恒定，因此Ass1是生成精氨酸的限速酶。本实验利用原位杂交和Real-timePCR检测了Ass1和Asl在围着床期小鼠子宫中的表达 ...
黄祝
core  

Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations

, 2017
Citrullinemia type 1 is an autosomal recessive urea cycle disorder caused by defects in the argininosuccinate synthetase (ASS) enzyme due to mutations in ASS1 gene.
Rüfenacht, Véronique, Diez-Fernandez, Carmen, Häberle, Johannes   +2 more
core   +1 more source

X-ray crystallographic studies of argininosuccinate synthetase

, 2002
Argininosuccinate synthetase (AS) is the rate-limiting enzyme of both the urea and arginine-citrulline cycles. In mammals, deficiency of AS leads to citrullinemia, a debilitating and often fatal autosomal recessive urea cycle disorder, whereas its ...
Lemke, Christopher Tony
core   +1 more source

Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines. [PDF]

Oncol Lett, 2018
Roeksomtawin S, Navasumrit P, Waraprasit S, Parnlob V, Sricharunrat T, Bhudhisawasdi V, Savaraj N, Ruchirawat M.   +7 more
europepmc   +1 more source