Results 81 to 90 of about 44,168 (193)

The Metabolic Regulatory Role of Argininosuccinate Synthetase (Ass) Under Heat Stress in Pacific Oyster (Crassostrea gigas)

Fishes
Marine heatwaves repeatedly trigger summer mortality of the farmed Pacific oyster (Crassostrea gigas), forcing its haemocytes to reprogramme metabolism under thermal stress. The metabolic nodes governing this adaptation remain poorly defined. Integrating
Haining Wang, Pengcheng Sun, Peng Li, Yang Ma, Jiarui Tong, Song Ma, Xueshu Zhang   +6 more
doaj   +1 more source

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Translational Oncology, 2020
Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg,
Macus Tien Kuo, Yan Long, Wen-Bin Tsai, Ying-Ying Li, Helen H.W. Chen, Lynn G. Feun, Niramol Savaraj   +6 more
doaj   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source

Supporting your practice: Compounding sodium benzoate oral liquid for urea cycle disorders

, 2021
Urea cycle disorders (UCD) are rare inherited metabolic disorders with an incidence estimated to be 1: 35,000 births. UCDs are caused by the dysfunction of any of the six enzymes (namely, carbamoyl phosphate synthetase I, N-acetylglutamate synthetase ...
Haywood, Alison, Glass, Beverley
core   +1 more source

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Cell Reports, 2017
Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Jeff Charles Kremer, Bethany Cheree Prudner, Sara Elaine Stubbs Lange, Gregory Richard Bean, Matthew Bailey Schultze, Caitlyn Brook Brashears, Megan DeAnna Radyk, Nathan Redlich, Shin-Cheng Tzeng, Kenjiro Kami, Laura Shelton, Aixiao Li, Zack Morgan, John Stephen Bomalaski, Takashi Tsukamoto, Jon McConathy, Loren Scott Michel, Jason Matthew Held, Brian Andrew Van Tine   +18 more
doaj   +1 more source

ASS1 Promotes Colorectal Cancer Immune Evasion Through CPT1A-Mediated S100A10 Succinylation

Frontiers in Bioscience-Landmark
Background: Colorectal cancer (CRC) progression is frequently driven by metabolic reprogramming and immune evasion. A crucial metabolic enzyme, argininosuccinate synthetase 1 (ASS1), is dysregulated in a number of malignancies; however,
Liping Sun, Daidi Fu, Heng Zhang
doaj   +1 more source

Electroencephalography and transcranial Doppler ultrasonography in neonatal citrullinemia

Journal of the Formosan Medical Association, 2014
The authors present a case of citrullinemia with a genotype of argininosuccinate synthetase (ASS1), c.380 G>A (p.R127Q)/c.380 G>A (p.R127Q), in two alleles. A 3-day-old female infant presented with status epilepticus and coma.
Pen-Hua Su, Jia-Yuh Chen, Yung-Jung Chen, Dau-Ming Niu, Ju-Hui Hsu, Inn-Chi Lee   +5 more
doaj   +1 more source

Decreased glutamine synthetase, increased citrulline–nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model [PDF]

, 2010
To understand their role in epilepsy, the nitric oxide synthetase (NOS), argininosuccinate synthetase (AS), argininosuccinate lyase (AL), glutamine synthetase (GS), and arginase activities, along with the concentration of nitrate/nitrite (NOx ...
Mummedy Swamy, Wan Yusof, Wan Roslina, Govindasamy, Chandran, Wan Roslina Wan Yusof, Sirajudeen, K. N. S., Mustapha, Zulkarnain, K. N. S. Sirajudeen, Chandran Govindasamy, Swamy, Mummedy, Zulkarnain Mustapha   +9 more
core   +1 more source

Comparison of two enzymes with similar substrate binding sites.

, 2013
The proteins involved are Serine racemase from Schizosaccharomyces pombe (2zpu, left) and Argininosuccinate synthetase from Thermus thermophilus (1kor, right).
Pier Federico Gherardini (90873), Gabriele Ausiello (10225), Manuela Helmer-Citterich (10228)   +2 more
core   +1 more source