Results 71 to 80 of about 44,168 (193)

Citrullinemia with an atypical presentation: Paroxysmal hypoventilation attacks

Journal of Pediatric Neurosciences, 2018
Citrullinemia type 1 (CTLN1) is a rare inherited urea cycle disorder, which resulted from the deficiency of argininosuccinate synthetase enzyme. We presented an infant who was hospitalized because of acute losses of tonus and cyanotic hypoventilation ...
Zeynep Öztürk, Tuğba Hirfanoğlu, Aslı İnci, İlyas Okur, Esin Koç, Leyla Tümer, Ebru Arhan, Kürşad Aydın, Ayşe Serdaroğlu   +8 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Modulation of intestinal urea cycle by dietary spermine in suckling rat

, 2005
peer reviewedArgininosuccinate synthetase, an ubiquitous enzyme in mammals, catalyses the formation of argininosuccinate, the precursor of arginine. Arginine is recognised as an essential amino acid in foetuses and neonates, but also as a conditionally ...
Powroznik, Brigitte, Rusu, Dorina, Mazzucchelli, Gabriel, Dandrifosse, Guy, Nollevaux, Géraldine, Gharbi, Myriam, Deville, Christelle, Peulen, Olivier   +7 more
core   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source

The pathway for urea cycle derived from KEGG pathway analysis.

, 2016
UM_WWY possess a gene encoding for a putative enzyme arginase (EC 3.5.3.1) which hydrolyzes arginine into ornithine and urea. EC 6.3.4.5 = Argininosuccinate synthetase; EC 4.3.2.1 = Argininosuccinate lyase; EC 2.1.3.3 = Ornithine transcarbamoylase.
Tze King Tan (2587147), Nicholas S. Jakubovics (282674), Siew Woh Choo (229018), Wei Yee Wee (407963)   +3 more
core   +1 more source

Studies on nitric oxide (No), citrulline-no cycle enzmes, arginase, glutamine synthetase and oxidative status in anoxia (Hypobaric Hypoxia) and reperfusion states in rat brain [PDF]

, 2012
Nitric oxide is postulated to be involved in the pathophysiology of neurological disorders due to hypoxia/ anoxia in brain due to increased release of glutamate and activation ofNmethyl- D-aspartate receptors.
Mummedy, Swamy
core   +1 more source

Effects of Dietary Sodium Butyrate on Growth Performance, Digestive Ability, Blood Biochemistry, and Ammonia Tolerance of Largemouth Bass (Micropterus salmoides)

Fishes
The aim of this study was to investigate the effects of sodium butyrate (SB) on growth performance, digestive ability, blood health, and ammonia tolerance of largemouth bass.
Xuan Chen, Wu Chen, Yanjie Tang, Muzi Zhang, Ming Li   +4 more
doaj   +1 more source

Pyrroloquinoline Quinone Attenuates Traumatic Brain Injury‐Induced Secondary Damage by Activating PINK1/Parkin‐Mediated Mitophagy and Suppressing ASS1/CPS1‐Driven Arginine Biosynthesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pyrroloquinoline quinone (PQQ) attenuates traumatic brain injury in mice. Multi‐omics integration and molecular docking reveal that PQQ activates PINK1/Parkin‐mediated mitophagy to restore mitochondrial homeostasis while suppressing ASS1/CPS1‐driven arginine biosynthesis to dampen neuroinflammation, identifying a dual‐axis therapeutic mechanism for TBI.
Yanan He, Lu Yu, Yixun Lu, Zhikang Zhou, Ao Li, Lu Wang, Zhili Huang, Yanhong Liu, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

Argininosuccinate Synthetase Activity in Parotid Glands

International Journal of Oral-Medical Sciences, 2005
In nitric oxide (NO)-generating cells, the citrulline/NO cycle is an important pathway in controlling the arginine supply because NO is generated from arginine by the activation of NO synthase. Argininosuccinate synthetase (AS ; EC 6.3.4.5) is a rate-limiting enzyme in the citrulline/NO cycle, which catalyses the condensation of citrulline and ...
Michikawa, Hiromi, Sairennji, Nakayasu, Kohgo, Hirohito, Shibutani, Koh, Furuyama, Shunsuke, Sugiya, Hiroshi   +5 more
openaire   +2 more sources

Transcript levels of genes encoding either urea cycle enzymes or enzymes in linked pathways determined at 400 ppm and 100 ppm CO₂ and standardized to PP2A.

, 2019
Data are the mean of five biological replicates ± SD. Significance was tested according to the two-tailed Student's t-test (* p2 ratios to allow this test.
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source