Results 91 to 100 of about 44,168 (193)

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer

Cells
Argininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Hila Tishler, Shahar Ziman, Kuoyuan Cheng, Kun Wang, Neel Sanghvi, Lital Adler, Gil Stelzer, Hillary Maniriho, Bareket Dassa, Elizabeta Bab-Dinitz, Michal Levi, Sivan Galai, Omer Goldman, Yarden Ariav, Naama Darzi, Saar Ezagouri, Nitsan Nimni, Nataly Rosenfeld, Ron Rotkopf, Alexander Brandis, Tevie Mehlman, Roni Oren, Mirie Zerbib, Yuri Kuznetsov, Sara Donzelli, Giovanni Blandino, Rony Seger, Eytan Ruppin, Ayelet Erez   +28 more
doaj   +1 more source

Suggested guidelines for the diagnosis and management of urea cycle disorders

Orphanet Journal of Rare Diseases, 2012
Urea cycle disorders (UCDs) are inborn errors of ammonia detoxification/arginine synthesis due to defects affecting the catalysts of the Krebs-Henseleit cycle (five core enzymes, one activating enzyme and one mitochondrial ornithine/citrulline antiporter)
Häberle Johannes, Boddaert Nathalie, Burlina Alberto, Chakrapani Anupam, Dixon Marjorie, Huemer Martina, Karall Daniela, Martinelli Diego, Crespo Pablo, Santer René, Servais Aude, Valayannopoulos Vassili, Lindner Martin, Rubio Vicente, Dionisi-Vici Carlo   +14 more
doaj   +1 more source

Role of 3'-Deoxy-3'-[¹⁸F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase. [PDF]

JTO Clin Res Rep, 2022
Szyszko TA, Dunn JT, Phillips MM, Bomalaski J, Sheaff MT, Ellis S, Pike L, Goh V, Cook GJR, Szlosarek PW.   +9 more
europepmc   +1 more source

Integration of metabolite and transcript data of ornithine-linked pathways.

, 2019
The squares indicate changes on both transcription and metabolic level in response to a CO2-shift from 400 ppm to 100 ppm (Student´s t-test ...
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene

, 2008
Citrullinemia type I is an autosomal recessive disorder that is caused by a deficiency of the urea cycle enzyme argininosuccinate synthetase (ASS1). Deficiency of ASS1 shows various clinical manifestations encompassing severely affected patients with ...
Engel, K, Johannes Häberle, Höhne, W, Häberle, J, Katharina Engel, Wolfgang Höhne   +5 more
core   +1 more source

Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

iScience
Summary: Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated ...
Josephine Carpentier, Marta Freitas, Valle Morales, Katiuscia Bianchi, John Bomalaski, Peter Szlosarek, Sarah A. Martin   +6 more
doaj   +1 more source

Model of reciprocal regulation of arginase 1 (ARG1) and nitric oxide synthase 2 (NOS2).

, 2015
Downstream metabolic products (blue framed) and their association with components of inflammatory responses (red). Enzymes (blue ellipses), NOHA: N-hydroxyarginine, OAT: ornithine aminotransferase, ODC: ornithine decarboxylase, ACL: argininosuccinate ...
Frieder Hadlich (732945), Wiebke Demasius (790105), Rosemarie Weikard (82446), Christa Kühn (790106)   +3 more
core   +1 more source

Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis

BMC Microbiology
The availability of nutrients is closely linked to the protein expression profile of microorganisms. In this study, a comparative investigation has been performed to examine the expression patterns of cell associated proteins and secreted proteins in ...
Wanting Zhu, Yujing Wang, Yanxin Li, Changjiang Zang, Hongning Jiang, Qijing Du, Jun Wang, Rongbo Fan, Rongwei Han, Yongxin Yang   +9 more
doaj   +1 more source

Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease.

, 2001
peer reviewedThe enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS).
Feinstein, Douglas L., Wiesinger, Heinrich, HENEKA, Michael, Riederer, Peter, Dumitrescu-Ozimek, Lucia, Klockgether, Thomas   +5 more
core   +1 more source