Results 1 to 10 of about 42,927 (266)

Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity [PDF]

eLife
RNA interference (RNAi) is a conserved pathway that utilizes Argonaute proteins and their associated small RNAs to exert gene regulatory function on complementary transcripts.
Shihui Chen, Carolyn Marie Phillips
doaj   +2 more sources

Asgard archaea defense systems and their roles in the origin of eukaryotic immunity [PDF]

Nature Communications
Dozens of new antiviral systems have been recently characterized in bacteria. Some of these systems are present in eukaryotes and appear to have originated in prokaryotes, but little is known about these defense mechanisms in archaea.
Pedro Leão, Mary E. Little, Kathryn E. Appler, Daphne Sahaya, Emily Aguilar-Pine, Kathryn Currie, Ilya J. Finkelstein, Valerie De Anda, Brett J. Baker   +8 more
doaj   +2 more sources

Functional diversification of Argonautes in nematodes:an expanding universe [PDF]

, 2013
In the last decade, many diverse RNAi (RNA interference) pathways have been discovered that mediate gene silencing at epigenetic, transcriptional and post-transcriptional levels. The diversity of RNAi pathways is inherently linked to the evolution of Ago
Amy H. Buck, Ashe, Bagijn, Batista, Baumberger, Blaxter, Bohmert, Cerutti, Chapman, Claycomb, Conine, Correa, Dalzell, Das, Diederichs, Felix, Fire, Fu, Gent, Gent, Ghildiyal, Gu, Huang, Hutvagner, Joshua-Tor, Ketting, Kim, Landthaler, Lee, Lin, Liu, Mark Blaxter, Metzlaff, Millar, Murphy, Obbard, Pak, Peters, Poole, Prochnik, Qi, Ruby, Sarkies, Shi, Shirayama, Sijen, Song, Vasale, Vaucheret, Wang, Winter, Yigit, Zilberman   +52 more
core   +3 more sources

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

eLife, 2022
MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly understood ...
Sean E McGeary, Namita Bisaria, Thy M Pham, Peter Y Wang, David P Bartel   +4 more
doaj   +1 more source

RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection

Frontiers in Microbiology, 2023
RNA interference (RNAi) is one of the important defense responses against viral infection, but its mechanism and impact remain unclear in mycovirus infections.
Yinhui Jiang, Yinhui Jiang, Xiang Liu, Xiang Liu, Xun Tian, Xun Tian, Jianhong Zhou, Jianhong Zhou, Qinrong Wang, Qinrong Wang, Bi Wang, Bi Wang, Wenfeng Yu, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi, Xiaolan Qi   +17 more
doaj   +1 more source

Barley Anther and Meiocyte Transcriptome Dynamics in Meiotic Prophase I

Frontiers in Plant Science, 2021
In flowering plants, successful germinal cell development and meiotic recombination depend upon a combination of environmental and genetic factors. To gain insights into this specialized reproductive development program we used short- and long-read RNA ...
Abdellah Barakate, Jamie Orr, Miriam Schreiber, Isabelle Colas, Dominika Lewandowska, Nicola McCallum, Malcolm Macaulay, Jenny Morris, Mikel Arrieta, Pete E. Hedley, Luke Ramsay, Robbie Waugh, Robbie Waugh, Robbie Waugh   +13 more
doaj   +1 more source

Understanding miRNA Based Gene Regulation in Parkinson’s Disease: An in silico Approach [PDF]

International Journal Bioautomation, 2020
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by depletion or insufficient release of dopaminergic neurons in substantia nigra of the midbrain.
Surya Narayan Rath, Manorama Patri
doaj   +1 more source

Characterization of a Programmable Argonaute Nuclease from the Mesophilic Bacterium Rummeliibacillus suwonensis

Biomolecules, 2022
Prokaryotic Argonautes (pAgos) from mesophilic bacteria are attracting increasing attention for their genome editing potential. So far, it has been reported that KmAgo from Kurthia massiliensis can utilize DNA and RNA guide of any sequence to effectively
Xiaoman Jiang, Yang Liu, Qi Liu, Lixin Ma   +3 more
doaj   +1 more source

ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. [PDF]

, 2014
Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5'-terminal nucleotide is important for sRNA sorting into different AGOs.
Carbonell, Alberto, Carrington, James C, Chang, Chia-en A, Jin, Hailing, Lee, Angel, Niu, DongDong, Tun, Vinnary, Wang, Airong, Wang, Zonghua, Zhang, Xiaoming   +9 more
core   +5 more sources

Innate Immunity Activation and RNAi Interplay in Citrus Exocortis Viroid—Tomato Pathosystem

Viruses, 2018
Although viroids are the smallest and simplest plant pathogens known, the molecular mechanisms underlying their pathogenesis remain unclear. To unravel these mechanisms, a dual approach was implemented consisting of in silico identification of potential ...
Thibaut Olivier, Claude Bragard
doaj   +1 more source