Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome [PDF]
Biomolecules, 2022 While host miRNA usually plays an antiviral role, the relentless tides of viral evolution have carved out a mechanism to recruit host miRNA as a viral protector.
Haiming Zhuang +8 more
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Imaging translational control by Argonaute with single-molecule resolution in live cells [PDF]
Nature Communications, 2022 Guided by miRNA, Argonaute proteins silence mRNA in multiple ways that are not well understood. Here, the authors develop live-cell biosensors to image the impact tethered regulatory factors, such as Argonaute, have on single-mRNA translation dynamics.
Charlotte A. Cialek +5 more
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A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins [PDF]
Advanced ScienceMounting evidence indicates that viruses exploit elevated reactive oxygen species (ROS) levels to promote replication and pathogenesis, yet the mechanistic underpinnings of this viral strategy remain elusive for many viral systems.
Shiyu Zhai +8 more
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GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins [PDF]
Nature, 2022 Amena Arif, Natsuko Izumi, Todd Anzelon
exaly +2 more sources
Biomolecules, 2022 Prokaryotic Argonautes (pAgos) from mesophilic bacteria are attracting increasing attention for their genome editing potential. So far, it has been reported that KmAgo from Kurthia massiliensis can utilize DNA and RNA guide of any sequence to effectively
Xiaoman Jiang +3 more
doaj +1 more source
Barley Anther and Meiocyte Transcriptome Dynamics in Meiotic Prophase I
Frontiers in Plant Science, 2021 In flowering plants, successful germinal cell development and meiotic recombination depend upon a combination of environmental and genetic factors. To gain insights into this specialized reproductive development program we used short- and long-read RNA ...
Abdellah Barakate +13 more
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RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection
Frontiers in Microbiology, 2023 RNA interference (RNAi) is one of the important defense responses against viral infection, but its mechanism and impact remain unclear in mycovirus infections.
Yinhui Jiang +17 more
doaj +1 more source
Structure of the guide-strand-containing argonaute silencing complex
Nature, 2008 Yanli Wang +2 more
exaly +3 more sources
Understanding miRNA Based Gene Regulation in Parkinson’s Disease: An in silico Approach [PDF]
International Journal Bioautomation, 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by depletion or insufficient release of dopaminergic neurons in substantia nigra of the midbrain.
Surya Narayan Rath, Manorama Patri
doaj +1 more source