Results 1 to 10 of about 47,693 (305)

Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity [PDF]

eLife
RNA interference (RNAi) is a conserved pathway that utilizes Argonaute proteins and their associated small RNAs to exert gene regulatory function on complementary transcripts.
Shihui Chen, Carolyn Marie Phillips
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Functional diversification of Argonautes in nematodes:an expanding universe [PDF]

, 2013
In the last decade, many diverse RNAi (RNA interference) pathways have been discovered that mediate gene silencing at epigenetic, transcriptional and post-transcriptional levels. The diversity of RNAi pathways is inherently linked to the evolution of Ago
Amy H. Buck, Ashe, Bagijn, Batista, Baumberger, Blaxter, Bohmert, Cerutti, Chapman, Claycomb, Conine, Correa, Dalzell, Das, Diederichs, Felix, Fire, Fu, Gent, Gent, Ghildiyal, Gu, Huang, Hutvagner, Joshua-Tor, Ketting, Kim, Landthaler, Lee, Lin, Liu, Mark Blaxter, Metzlaff, Millar, Murphy, Obbard, Pak, Peters, Poole, Prochnik, Qi, Ruby, Sarkies, Shi, Shirayama, Sijen, Song, Vasale, Vaucheret, Wang, Winter, Yigit, Zilberman   +52 more
core   +3 more sources

Imaging translational control by Argonaute with single-molecule resolution in live cells

Nature Communications, 2022
Guided by miRNA, Argonaute proteins silence mRNA in multiple ways that are not well understood. Here, the authors develop live-cell biosensors to image the impact tethered regulatory factors, such as Argonaute, have on single-mRNA translation dynamics.
Charlotte A. Cialek, Gabriel Galindo, Tatsuya Morisaki, Ning Zhao, Taiowa A. Montgomery, Timothy J. Stasevich   +5 more
doaj   +2 more sources

Asgard archaea defense systems and their roles in the origin of eukaryotic immunity [PDF]

Nature Communications
Dozens of new antiviral systems have been recently characterized in bacteria. Some of these systems are present in eukaryotes and appear to have originated in prokaryotes, but little is known about these defense mechanisms in archaea.
Pedro Leão, Mary E. Little, Kathryn E. Appler, Daphne Sahaya, Emily Aguilar-Pine, Kathryn Currie, Ilya J. Finkelstein, Valerie De Anda, Brett J. Baker   +8 more
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Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination

Frontiers in Cell and Developmental Biology, 2020
The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several human ...
Madlen Müller, Madlen Müller, Francesco Fazi, Constance Ciaudo   +3 more
doaj   +2 more sources

Argonaute proteins: Structural features, functions and emerging roles

Journal of Advanced Research, 2020
Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing ...
Jin'en Wu, Jing Yang, William C. Cho, Yadong Zheng   +3 more
doaj   +2 more sources

DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins

Nature Communications, 2018
In this review, Aravin and colleagues examine bacterial and archaeal Argonaute proteins, discuss their diverse architectures and their possible roles in host defense, proposing additional functions for Argonaute proteins in prokaryotic cells.
Lidiya Lisitskaya, Alexei A. Aravin, Andrey Kulbachinskiy   +2 more
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MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

eLife, 2022
MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly understood ...
Sean E McGeary, Namita Bisaria, Thy M Pham, Peter Y Wang, David P Bartel   +4 more
doaj   +1 more source

RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection

Frontiers in Microbiology, 2023
RNA interference (RNAi) is one of the important defense responses against viral infection, but its mechanism and impact remain unclear in mycovirus infections.
Yinhui Jiang, Yinhui Jiang, Xiang Liu, Xiang Liu, Xun Tian, Xun Tian, Jianhong Zhou, Jianhong Zhou, Qinrong Wang, Qinrong Wang, Bi Wang, Bi Wang, Wenfeng Yu, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi, Xiaolan Qi   +17 more
doaj   +1 more source

Barley Anther and Meiocyte Transcriptome Dynamics in Meiotic Prophase I

Frontiers in Plant Science, 2021
In flowering plants, successful germinal cell development and meiotic recombination depend upon a combination of environmental and genetic factors. To gain insights into this specialized reproductive development program we used short- and long-read RNA ...
Abdellah Barakate, Jamie Orr, Miriam Schreiber, Isabelle Colas, Dominika Lewandowska, Nicola McCallum, Malcolm Macaulay, Jenny Morris, Mikel Arrieta, Pete E. Hedley, Luke Ramsay, Robbie Waugh, Robbie Waugh, Robbie Waugh   +13 more
doaj   +1 more source