Results 11 to 20 of about 30,324 (235)
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
eLife, 2021 Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing.
Heesun Kim +6 more
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Argonaute and Argonaute-Bound Small RNAs in Stem Cells [PDF]
International Journal of Molecular Sciences, 2016 Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals.
Zhai, Lihong +7 more
openaire +6 more sources
The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy
Molecular Therapy: Nucleic Acids, 2014 Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
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Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi [PDF]
Nature Communications, 2017 While RNA interference is a highly conserved mechanism of gene regulation, how Argonaute-bound small RNAs are targeted for degradation is not well understood.
Paola Pisacane, Mario Halic
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Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens [PDF]
Advanced scienceThis study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Huang F +9 more
europepmc +2 more sources
Argonaute proteins: structures and their endonuclease activity
, 2021 Argonaute proteins are highly conserved and widely expressed in almost all organisms. They not only play a critical role in the biogenesis of small RNAs but also defend against invading nucleic acids via small RNA or DNA-mediated gene silencing pathways.
Zhan, Jian +5 more
core +1 more source
Targeting Argonaute to chromatin [PDF]
Genes & Development, 2016 In many eukaryotes, siRNAs bound to Argonaute proteins guide chromatin-modifying enzymes to complementary loci, resulting in transcriptional gene silencing. Multiple lines of evidence indicate that siRNAs base-pair with longer RNAs produced at target loci, but the possibility that siRNAs base-pair directly with DNA remains an attractive hypothesis.
Wendte, Jered M., Pikaard, Craig S.
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Knocking out the Argonautes [PDF]
Cell, 2006 Argonaute proteins are key players in gene silencing involving small RNAs. In this issue, Yigit et al. (2006) report a comprehensive study of Argonautes in the worm that places many of the 27 family members into a complex gene-silencing network.
Steiner, F.A., Plasterk, R.H.A.
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The Argonaute protein family [PDF]
Genome Biology, 2008 Argonaute proteins were first discovered genetically, and extensive research in the past few years has revealed that members of the Argonaute protein family are key players in gene-silencing pathways guided by small RNAs. Small RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs) or Piwi-interacting RNAs (piRNAs) are anchored into specific ...
Höck, J., Meister, G.
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Cold Spring Harbor Symposia on Quantitative Biology, 2006 RNA interference (RNAi) has been greatly exploited in recent years as an increasingly effective tool to study gene function by gene silencing. The introduction of exogenous double-stranded RNA (dsRNA) into a cell can trigger this gene silencing process.
openaire +2 more sources