Results 11 to 20 of about 24,859 (201)
Cold Spring Harbor Symposia on Quantitative Biology, 2006 RNA interference (RNAi) has been greatly exploited in recent years as an increasingly effective tool to study gene function by gene silencing. The introduction of exogenous double-stranded RNA (dsRNA) into a cell can trigger this gene silencing process.
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Knocking out the Argonautes [PDF]
Cell, 2006 Argonaute proteins are key players in gene silencing involving small RNAs. In this issue, Yigit et al. (2006) report a comprehensive study of Argonautes in the worm that places many of the 27 family members into a complex gene-silencing network.
Steiner, F.A., Plasterk, R.H.A.
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Molecular Cell, 2013 In this issue of Molecular Cell, De et al. (2013) report that highly complementary targets promote release of small RNAs from effector Argonaute complexes, thus providing mechanistic insights into regulation of small RNA stability and implications for siRNA design.
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Argonaute proteins at a glance [PDF]
Journal of Cell Science, 2010 Although a large portion of the human genome is actively transcribed into RNA, less than 2% encodes proteins. Most transcripts are non-coding RNAs (ncRNAs), which have various cellular functions. Small ncRNAs (or small RNAs) – ncRNAs that are characteristically ~20-35 nucleotides long – are required for the regulation of gene expression in many ...
Ender, Christine, Meister, Gunter
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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
eLife, 2021 Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear.
Gaspare La Rocca +19 more
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Non-Coding RNA, 2023 Aging in women is accompanied by a dramatic change in circulating sex steroid hormones. Specifically, the primary circulating estrogen, 17β-estradiol (E2), is nearly undetectable in post-menopausal women.
Megan L. Linscott +4 more
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MicroRNA-mediated gene silencing: are we close to a unifying model?
Biomolecular Concepts, 2012 MicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA).
James Victoria +2 more
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AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis
Plants, 2020 Small RNA (sRNA) turnover is a key but poorly understood mechanism that determines the homeostasis of sRNAs. Animal XRN genes contribute the degradation of sRNAs, AtXRN2 and AtXRN3 also contribute the pri-miRNA processing and miRNA loop degradation in ...
Yan Liu +7 more
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Innate Immunity Activation and RNAi Interplay in Citrus Exocortis Viroid—Tomato Pathosystem
Viruses, 2018 Although viroids are the smallest and simplest plant pathogens known, the molecular mechanisms underlying their pathogenesis remain unclear. To unravel these mechanisms, a dual approach was implemented consisting of in silico identification of potential ...
Thibaut Olivier, Claude Bragard
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Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome
Biomolecules, 2022 While host miRNA usually plays an antiviral role, the relentless tides of viral evolution have carved out a mechanism to recruit host miRNA as a viral protector.
Haiming Zhuang +8 more
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