Results 21 to 30 of about 24,859 (201)
AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals
Frontiers in Bioscience-Landmark, 2020 Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex ...
Laura Sala +2 more
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Nitro Reduction‐Based RNA Control and Ultrafast Release
Angewandte Chemie, EarlyView.A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao +6 more
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Expansion and Divergence of Argonaute Genes in the Oomycete Genus Phytophthora
Frontiers in Microbiology, 2018 Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the
Stephanie R. Bollmann +3 more
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From transcription to translation: new insights in the structure and function of Argonaute protein
Biomolecular Concepts, 2012 Argonaute proteins play a central role in gene silencing pathways mediated by small RNA molecules. The ancestral function of small RNA-dependent silencing is related to genome protection against parasitic nucleic acids, such as transposons and viruses ...
Giorgi Corinna +2 more
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Are Argonaute-Associated Tiny RNAs Junk, Inferior miRNAs, or a New Type of Functional RNAs?
Frontiers in Molecular Biosciences, 2021 The biosynthesis pathways of microRNAs (miRNAs) have been well characterized with the identification of the required components. miRNAs are synthesized from the transcripts of miRNA genes and other RNAs, such as introns, transfer RNAs, ribosomal RNAs ...
Kotaro Nakanishi, Kotaro Nakanishi
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Frontiers in Plant Science, 2022 Plant argonautes (AGOs) play important roles in the defense responses against viruses. The expression of Nicotiana benthamiana AGO5 gene (NbAGO5) is highly induced by Bamboo mosaic virus (BaMV) infection; however, the underlying mechanisms remain elusive.
Yuan-Dun Ke +11 more
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Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes
Molecular Therapy: Nucleic Acids, 2018 MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs).
Yasuhiro Mie +6 more
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Differentiation among the ARGONAUTES [PDF]
The Plant Cell, 2010 Noncoding RNAs, including small RNAs (sRNAs), act in an astonishing variety of cellular processes, including gene expression, heterochromatin dynamics, and regulation of development (reviewed in [Amaral et al., 2008][1]), and ARGONAUTE (AGO) proteins are key effectors of these processes ...
openaire +2 more sources
The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy
Molecular Therapy: Nucleic Acids, 2014 Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
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In Silico Identification, Phylogenetic and Bioinformatic Analysis of Argonaute Genes in Plants
International Journal of Genomics, 2014 Argonaute protein family is the key players in pathways of gene silencing and small regulatory RNAs in different organisms. Argonaute proteins can bind small noncoding RNAs and control protein synthesis, affect messenger RNA stability, and even ...
Khaled Mirzaei +3 more
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