Results 21 to 30 of about 30,324 (235)
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements [PDF]
, 2009 Background In eukaryotes, RNA interference (RNAi) is a major mechanism of defense against viruses and transposable elements as well of regulating translation of endogenous mRNAs.
Makarova, K.S. +11 more
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Molecular Cell, 2013 In this issue of Molecular Cell, De et al. (2013) report that highly complementary targets promote release of small RNAs from effector Argonaute complexes, thus providing mechanistic insights into regulation of small RNA stability and implications for siRNA design.
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Argonaute proteins at a glance [PDF]
Journal of Cell Science, 2010 Although a large portion of the human genome is actively transcribed into RNA, less than 2% encodes proteins. Most transcripts are non-coding RNAs (ncRNAs), which have various cellular functions. Small ncRNAs (or small RNAs) – ncRNAs that are characteristically ~20-35 nucleotides long – are required for the regulation of gene expression in many ...
Ender, Christine, Meister, Gunter
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Functional diversification of Argonautes in nematodes:an expanding universe [PDF]
, 2013 In the last decade, many diverse RNAi (RNA interference) pathways have been discovered that mediate gene silencing at epigenetic, transcriptional and post-transcriptional levels. The diversity of RNAi pathways is inherently linked to the evolution of Ago
Buck, Amy H, Blaxter, Mark
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AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis
Plants, 2020 Small RNA (sRNA) turnover is a key but poorly understood mechanism that determines the homeostasis of sRNAs. Animal XRN genes contribute the degradation of sRNAs, AtXRN2 and AtXRN3 also contribute the pri-miRNA processing and miRNA loop degradation in ...
Yan Liu +7 more
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Non-Coding RNA, 2023 Aging in women is accompanied by a dramatic change in circulating sex steroid hormones. Specifically, the primary circulating estrogen, 17β-estradiol (E2), is nearly undetectable in post-menopausal women.
Megan L. Linscott +4 more
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RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops. [PDF]
Adv Sci (Weinh)This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Zhang X +13 more
europepmc +2 more sources
MicroRNA-mediated gene silencing: are we close to a unifying model?
Biomolecular Concepts, 2012 MicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA).
James Victoria +2 more
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Evolution of Dicer and Argonaute orthologs in microsporidian parasites [PDF]
, 2018 Microsporidia are a group of intracellular parasites which infect animal hosts. The infection can broadly influence the hosts' metabolism, growth as well as immune responses.
Huang, Qiang, Huang Q
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Innate Immunity Activation and RNAi Interplay in Citrus Exocortis Viroid—Tomato Pathosystem
Viruses, 2018 Although viroids are the smallest and simplest plant pathogens known, the molecular mechanisms underlying their pathogenesis remain unclear. To unravel these mechanisms, a dual approach was implemented consisting of in silico identification of potential ...
Thibaut Olivier, Claude Bragard
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