Results 31 to 40 of about 30,324 (235)
AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals
Frontiers in Bioscience-Landmark, 2020 Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex ...
Laura Sala +2 more
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Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome
Biomolecules, 2022 While host miRNA usually plays an antiviral role, the relentless tides of viral evolution have carved out a mechanism to recruit host miRNA as a viral protector.
Haiming Zhuang +8 more
doaj +1 more source
A Systematic Analysis of Argonaute Proteins in Caenorhabditis elegans [PDF]
, 2021 RNA interference (RNAi) pathways, consisting of Argonaute proteins and small RNAs that provide sequence specificity, play key roles in gene regulation across all domains of life.
Seroussi, Uri
core
Expansion and Divergence of Argonaute Genes in the Oomycete Genus Phytophthora
Frontiers in Microbiology, 2018 Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the
Stephanie R. Bollmann +3 more
doaj +1 more source
From transcription to translation: new insights in the structure and function of Argonaute protein
Biomolecular Concepts, 2012 Argonaute proteins play a central role in gene silencing pathways mediated by small RNA molecules. The ancestral function of small RNA-dependent silencing is related to genome protection against parasitic nucleic acids, such as transposons and viruses ...
Giorgi Corinna +2 more
doaj +1 more source
Are Argonaute-Associated Tiny RNAs Junk, Inferior miRNAs, or a New Type of Functional RNAs?
Frontiers in Molecular Biosciences, 2021 The biosynthesis pathways of microRNAs (miRNAs) have been well characterized with the identification of the required components. miRNAs are synthesized from the transcripts of miRNA genes and other RNAs, such as introns, transfer RNAs, ribosomal RNAs ...
Kotaro Nakanishi, Kotaro Nakanishi
doaj +1 more source
To degrade a microRNA, destroy its argonaute protein
, 2021 Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome.
Zamore, Phillip D +3 more
core +1 more source
Frontiers in Plant Science, 2022 Plant argonautes (AGOs) play important roles in the defense responses against viruses. The expression of Nicotiana benthamiana AGO5 gene (NbAGO5) is highly induced by Bamboo mosaic virus (BaMV) infection; however, the underlying mechanisms remain elusive.
Yuan-Dun Ke +11 more
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Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes
Molecular Therapy: Nucleic Acids, 2018 MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs).
Yasuhiro Mie +6 more
doaj +1 more source
Anti-miRs competitively inhibit microRNAs in Argonaute complexes. [PDF]
, 2014 MicroRNAs (miRNAs), small RNA molecules that post-transcriptionally regulate mRNA expression, are crucial in diverse developmental and physiological programs and their misregulation can lead to disease.
Dimitrios G Zisoulis +25 more
core +1 more source