Results 51 to 60 of about 30,324 (235)

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

A DNA-guided prokaryotic argonaute enables programmable RNA cleavage for sequencing and quality control of in vitro-transcribed RNAs

Molecular Therapy: Nucleic Acids
Argonaute (Ago) endonucleases are ubiquitous across all domains of life and, like Cas nucleases, can be programmed by guide oligonucleotides to target and cleave specific nucleic acid sequences.
Lizhi Liu, Eric A. Hunt, Eric J. Wolf, Ivan R. Corrêa, Jr., Erbay Yigit, Sebastian Grünberg   +5 more
doaj   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Argonaute slicing is required for heterochromatic silencing and spreading

, 2006
Small interfering RNA (siRNA) guides dimethylation of histone H3 lysine-9 (H3K9me2) via the Argonaute and RNA-dependent RNA polymerase complexes, as well as base-pairing with either RNA or DNA.
Zaratiegui, M., Martienssen, R. A., Joshua-Tor, L., Zaratiegui, Mi., Tolia, N. H., Joshua-Tor, L., Irvine, D. V., Martienssen, R.A., Chitwood, D. H., Rolia, N.H., Vaughn, M. W., Irvine, D.V., Goto, D. B., Goto, D.B., Chitwood, D.H., Vaughn, M.W.   +15 more
core   +1 more source

Structural and Evolutionary Determinants of Argonaute Function [PDF]

Nucleic Acids Research
Mathew Van de Pette, Arndt Wallmann
exaly   +2 more sources

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science
Mounting evidence indicates that viruses exploit elevated reactive oxygen species (ROS) levels to promote replication and pathogenesis, yet the mechanistic underpinnings of this viral strategy remain elusive for many viral systems.
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
doaj   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana [PDF]

Plant Genome
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Feng Z, Yin X, Jiang Z, Yao J, Dong Y, Ma X, Meng Y.   +6 more
europepmc   +2 more sources

Combinatorial Tuning of Multigene Biosynthetic Pathways based on RNA Interference

Advanced Science, EarlyView.
Small RNA sequencing identifies candidate endogenous Pol III promoters, and subsequent fluorescence screening measures knockdown efficiency to assess promoter strength. Combining promoter strength and shRNA target position enables fine‐grained RNAi regulation of multigene pathways. This strategy enhances β‐carotene production in Schizochytrium sp.
Zixu Zhang, Yingshuang Xu, Zijia Li, Fei Du, Wang Ma, Guang Yang, Xiaoman Sun   +6 more
wiley   +1 more source

Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis

eLife, 2016
Small RNAs are central players in RNA silencing, yet their cytoplasmic compartmentalization and the effects it may have on their activities have not been studied at the genomic scale.
Shengben Li, Brandon Le, Xuan Ma, Shaofang Li, Chenjiang You, Yu Yu, Bailong Zhang, Lin Liu, Lei Gao, Ting Shi, Yonghui Zhao, Beixin Mo, Xiaofeng Cao, Xuemei Chen   +13 more
doaj   +1 more source