Results 61 to 70 of about 30,324 (235)

Imaging translational control by Argonaute with single-molecule resolution in live cells

Nature Communications, 2022
Guided by miRNA, Argonaute proteins silence mRNA in multiple ways that are not well understood. Here, the authors develop live-cell biosensors to image the impact tethered regulatory factors, such as Argonaute, have on single-mRNA translation dynamics.
Charlotte A. Cialek, Gabriel Galindo, Tatsuya Morisaki, Ning Zhao, Taiowa A. Montgomery, Timothy J. Stasevich   +5 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

The evolutionary journey of Argonaute proteins

, 2014
Argonaute proteins are conserved throughout all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference, whereas eukaryotic Argonaute proteins (eAgos) control a wide range of ...
Dinshaw J Patel, Koonin, E.V., Oost, J., van der, Nakanishi, K., John van der Oost, Patel, D.J., Yanli Wang, Daan C Swarts, Ketting, R.F., Kira Makarova, Wang, Y., René F Ketting, Swarts, D.C., Kotaro Nakanishi, Makarova, K., Eugene V Koonin   +15 more
core   +1 more source

Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin [PDF]

, 2015
High-throughput sequencing reveals an abundance of microRNA-sized fragments derived from larger non-coding RNAs. Roles for these small RNAs in gene silencing are suggested by their co-precipitation with Argonaute, the microRNA effector protein, though ...
Lawrence, D., Toubia, J., Bracken, C., Goodall, G., Thomson, D., Pillman, K., Anderson, M.   +6 more
core   +1 more source

In Silico Identification, Phylogenetic and Bioinformatic Analysis of Argonaute Genes in Plants

International Journal of Genomics, 2014
Argonaute protein family is the key players in pathways of gene silencing and small regulatory RNAs in different organisms. Argonaute proteins can bind small noncoding RNAs and control protein synthesis, affect messenger RNA stability, and even ...
Khaled Mirzaei, Bahman Bahramnejad, Mohammad Hasan Shamsifard, Wahid Zamani   +3 more
doaj   +1 more source

MicroRNA‐210 level as a biomarker for pre‐eclampsia severity: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Pre‐eclampsia is a serious pregnancy‐related syndrome lacking accurate prognostic markers. MicroRNA‐210, overexpressed in the circulation of women with pre‐eclampsia, has recently emerged as a promising biomarker. Objectives We conducted a systematic review and meta‐analysis to evaluate the relationship between miR‐210 levels and ...
Dávid Márai, Isabel Pinto Amorim das Virgens, Ádám Vincze, Mahmoud Obeidat, Péter Hegyi, Mikolt Bakony, Zsófia Réka Erdélyi, Zsolt Melczer, Sándor Valent   +8 more
wiley   +1 more source

Evolution of RNA interference proteins dicer and argonaute in Basidiomycota

, 2013
RNA interference (RNAi) refers to a mechanism in which cells control gene expression, protect the genome against mobile repetitive DNA sequences, retro elements and transposons, and defend themself against viruses.
Stenlid, Jan,, Hu, Yang,, Olson, Åke,, Sveriges lantbruksuniversitet., Elfstrand, Malin,, Swedish University of Agricultural Sciences.   +5 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Argonaute proteins couple chromatin silencing to alternative splicing

, 2012
International audienceArgonaute proteins play a major part in transcriptional gene silencing in many organisms, but their role in the nucleus of somatic mammalian cells remains elusive. Here, we have immunopurified human Argonaute-1 and Argonaute-2 (AGO1
Robert Young, Jean-Christophe Andrau, Christian Muchardt, Christophe Rachez, Jacques Mathieu, Nicolas Descostes, Fenouil, Romain, Romain Fenouil, Batsché, Eric, Andrau, Jean-Christophe, Annick Harel-Bellan, Mouloud Souidi, Ali Hamiche, Harel-Bellan, Annick, Lauriane Fritsch, Rachez, Christophe, Philippe Robin, Ait-Si-Ali, Slimane, Eric Batsché, Ameyar-Zazoua, Maya, Nadya Morozova, Muchardt, Christian, Morozova, Nadya, Fritsch, Lauriane, Souidi, Mouloud, Young, Robert, Mathieu, Jacques, Descostes, Nicolas, Robin, Philippe, Maya Ameyar-Zazoua, Hamiche, Ali, Slimane Ait-Si-Ali   +31 more
core   +1 more source

A TtAgo‐Driven Autocatalytic Circuit with Thermal‐Enhanced Kinetics for One‐Pot Nucleic Acid Detection

Advanced Science
Catalytic DNA circuits hold significant promise for nucleic‐acid‐based diagnostics, yet they remain hindered by slow reaction kinetics and the non‐universal nature of one‐pot approaches.
Zuowei Xie, Ruijia Deng, Ben Niu, Yingjie Yang, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jie Luo, Yu Tang, Jing Sheng, Yan Pi, Ming Chen, Kai Chang   +12 more
doaj   +1 more source