Results 61 to 70 of about 24,859 (201)

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Domain motions of Argonaute, the catalytic engine of RNA interference

BMC Bioinformatics, 2007
Background The Argonaute protein is the core component of the RNA-induced silencing complex, playing the central role of cleaving the mRNA target. Visual inspection of static crystal structures already has enabled researchers to suggest conformational ...
Wall Michael E, Ming Dengming, Sanbonmatsu Kevin Y   +2 more
doaj   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source

Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles

Children
Background: Argonautes (AGOs) are a type of protein that degrade specific messenger RNAs, consequently reducing the expression of a specific gene. These proteins consist of small, single-stranded RNA or DNA and may provide a route for detecting and ...
Zon-Min Lee, Hui-Chuan Chang, Shih-Feng Liu, Ying-Hsien Huang, Ho-Chang Kuo   +4 more
doaj   +1 more source

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, EarlyView.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source

DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins

Nature Communications, 2018
In this review, Aravin and colleagues examine bacterial and archaeal Argonaute proteins, discuss their diverse architectures and their possible roles in host defense, proposing additional functions for Argonaute proteins in prokaryotic cells.
Lidiya Lisitskaya, Alexei A. Aravin, Andrey Kulbachinskiy   +2 more
doaj   +1 more source

A platform for analyzing translational control by RBPs at single-mRNA resolution in cells

Biophysics and Physicobiology
Translation—the process by which mRNAs are decoded into nascent peptides—is fundamental to life. This process is regulated by various RNA-binding proteins (RBPs), which interact with their target mRNAs.
Hotaka Kobayashi, Robert H. Singer
doaj   +1 more source

Variation and Evolution in the Glutamine-Rich Repeat Region of Drosophila Argonaute-2

G3: Genes, Genomes, Genetics, 2016
RNA interference pathways mediate biological processes through Argonaute-family proteins, which bind small RNAs as guides to silence complementary target nucleic acids .
William H. Palmer, Darren J. Obbard
doaj   +1 more source