Results 91 to 100 of about 43,543 (282)
Pest Management Science, EarlyView.RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden +3 more
wiley +1 more source
Intramyocardial gene silencing by interfering RNA [PDF]
, 2017 RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases havea high incidence in
Brea, María Soledad +2 more
core +1 more source
siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 [PDF]
, 2016 Efficient gene silencing by RNA interference (RNAi) in vivo requires the recognition and binding of the 5'- phosphate of the guide strand of an siRNA by the Argonaute protein.
Brown, C. R. +6 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Therapeutic oligonucleotides (TOs) represent an emerging modality, which offers a promising alternative treatment option, particularly for intracellular targets. The two types of TOs, antisense oligonucleotides (ASO) and small interfering RNAs (siRNAs), distribute highly into tissues, especially into the liver and the kidneys.
Felix Stader +5 more
wiley +1 more source
Argonaute proteins: Structural features, functions and emerging roles
Journal of Advanced Research, 2020 Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing ...
Jin'en Wu +3 more
doaj +1 more source
The \u3cem\u3emir-51\u3c/em\u3e Family of MicroRNAs Functions in Diverse Regulatory Pathways in \u3cem\u3eCaenorhbditis elegans\u3c/em\u3e [PDF]
, 2012 The mir-51 family of microRNAs (miRNAs) in C. elegans are part of the deeply conserved miR-99/100 family. While loss of all six family members (mir-51-56) in C. elegans results in embryonic lethality, loss of individual mir-51 family members results in a
Abbott, Allison L. +2 more
core +1 more source
UroPrecision, EarlyView.Abstract Prostate cancer (PCa) is a multifaceted disease that envelops 1.41 million new cases globally. It is the second most common cancer reported in men. Its heterogeneity and indolent growth, coupled with incompetent early screening methods such as serum prostate‐specific antigen level estimations and digital rectal examinations, contribute to its ...
Anveshika Manoj +2 more
wiley +1 more source
Functional dissection of a plant Argonaute [PDF]
Nucleic Acids Research, 2015 RNA guided ribonuclease complexes play central role in RNA interference. Members of the evolutionarily conserved Argonaute protein family form the catalytic cores of these complexes. Unlike a number of other plant Argonautes, the role of AGO2 has been obscure until recently.
Márta Ludman +2 more
openaire +3 more sources
Insect Science, EarlyView.This study introduces a microinjection technique to deliver dsRNA into the hemolymph of first instar larval thrips (L1s) via the foreleg coxa, enhancing survival rates by minimizing internal tissue damage. Significant knockdown of V‐ATPase‐B, CYP3653A2, and ApoLp‐II/I was achieved, with silencing of CYP3653A2 or ApoLp‐II/I increasing larval mortality ...
Jinlong Han, Dorith Rotenberg
wiley +1 more source
Progress in micro RNA focused research in endocrinology
Endocrine Regulations, 2016 Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its ...
Voglova K., Bezakova J., Herichova Iveta
doaj +1 more source