Results 91 to 100 of about 25,854 (244)
Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley +1 more source
Sural/Radial Amplitude Ratio: A Useful Tool to Diagnose Non‐Length‐Dependent Neuropathy
ABSTRACT Introduction/Aims Patients with non‐length‐dependent neuropathy (NLDN) exhibit reduced sensory nerve action potential (SNAP) amplitudes in both lower and upper limbs. This study aimed to determine a threshold for the sural/radial amplitude ratio (SRAR) suggestive of NLDN.
Antoine Pegat +6 more
wiley +1 more source
VCP Machinery Mediates Autophagic Degradation of Empty Argonaute
Summary: The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species.
Hotaka Kobayashi +4 more
doaj +1 more source
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides [PDF]
William E. Salomon +4 more
openalex +1 more source
Argonaute proteins: potential biomarkers for human colon cancer
Background Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions in human disease.
Gao Hengjun +3 more
doaj +1 more source
Functional dissection of a plant Argonaute [PDF]
Károly Fátyol +2 more
openalex +1 more source
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente +4 more
wiley +1 more source
The Roles of Plant MicroRNAs in Defence Against Pathogens
miRNAs modulate plant immunity against various pathogens, including fungi, bacteria, viruses, nematodes and oomycetes, by targeting pathogen effectors and modulating hormonal signalling. ABSTRACT MicroRNAs (miRNAs) are a class of noncoding RNAs that play important roles in regulating gene expression.
Abdou Mahaman Mahamadou +6 more
wiley +1 more source
Plant virus‐mediated induction of miR168 is associated with repression of
Éva Várallyay +4 more
openalex +1 more source
ABSTRACT Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population, widespread adoption of sedentary lifestyles, and
Michael Macleod +5 more
wiley +1 more source

