Results 91 to 100 of about 47,693 (305)

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources

A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
The ssLAMP method amplifies the nucleic acid of pathogen and identifies SNP mutations. By combining the portable detection device with smartphone‐based analysis software, enables rapid, on‐site SNP detection and genotyping of SARS‐Cov‐2 Omicron variants, providing a cost‐effective and field‐deployable solution for precise pathogen identification in ...
Qijie Lin, Hongchao Gou, Xiaoyun Qu, Kaiyuan Jia, Yuhui Deng, Dan Li, Qianyi Cai, Yucen Liang, Xiaozhen Xu, Yanbin Li, Jianhan Lin, Letian Li, Yuhang Jiang, Shouwen Du, Lingcong Deng, Bailing Yan, Ruidong Liu, Chang Li, Jianmin Zhang, Ming Liao   +19 more
wiley   +1 more source

Antiviral roles of plant ARGONAUTES

Current Opinion in Plant Biology, 2015
ARGONAUTES (AGOs) are the effector proteins functioning in eukaryotic RNA silencing pathways. AGOs associate with small RNAs and are programmed to target complementary RNA or DNA. Plant viruses induce a potent and specific antiviral RNA silencing host response in which AGOs play a central role.
CARBONELL, ALBERTO, Carrington, James C.
openaire   +4 more sources

Argonauts Of The Western Pacific

Setelah pembahasan yang agak panjang tentang ilmu sihir, sekarang kita dapat kembali lagi ke deskripsi tentang Kula. Sejauh ini, kita hanya membahas satu kejadian di dalamnya, ekspedisi luar negeri antara Sinaketa dan Dobu, dan kunjungan balasan. Namun, dalam membahas satu tahap khas ini, kita telah memperoleh gambaran tentang seluruh Kula, dan secara ...
  +7 more sources

RNAi and retroviruses: are they in RISC?

Biomolecular Concepts, 2013
RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex.
Vasselon Thierry, Bouttier Manuella, Saumet Anne, Lecellier Charles-Henri   +3 more
doaj   +1 more source

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute

bioRxiv, 2019
Prokaryotic Argonaute proteins (pAgos) constitute a diverse group of endonucleases of which some mediate host defense by utilizing small interfering DNA guides (siDNA) to cleave complementary invading DNA.
Jorrit W. Hegge, D. C. Swarts, S. D. Chandradoss, T. J. Cui, Jeroen Kneppers, M. Jinek, Chirlmin Joo, John van der Oost   +7 more
semanticscholar   +1 more source

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

DNA recognition by an RNA-guided bacterial Argonaute. [PDF]

PLoS ONE, 2017
Argonaute (Ago) proteins are widespread in prokaryotes and eukaryotes and share a four-domain architecture capable of RNA- or DNA-guided nucleic acid recognition. Previous studies identified a prokaryotic Argonaute protein from the eubacterium Marinitoga
Kevin W Doxzen, Jennifer A Doudna
doaj   +1 more source

Modeling recursive RNA interference. [PDF]

, 2008
An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
A Dillin, A Grishok, A Reynolds, AA Andronow, AS Peek, C Gerner, CC Mello, CT Bergstrom, D Schmitter, DC Baulcombe, DW Bartlett, E Bernstein, E Koller, E Yang, FJ Isaacs, GL Tang, J Pak, J Yu, J Zhang, JC Arciero, JJ MacRae, JK Kim, John S. Mattick, JP Vert, K Ui-Tei, M Kaern, M Wiznerowicz, MAC Groenenbom, MC Saleh, MT McManus, MW Rhoades, N Bushati, N Doi, NR Dudley, NT Hoa, P Jia, Q Liu, S Dorner, SM Elbashir, SM Hammond, T Holen, T Sijen, T Tuschl, TA Vickers, TL Deans, U Alon, Wallace F. Marshall, X Darzacq, X Huang, XD Zhang, XS Ke, Y Tomari, Z Xie   +52 more
core   +5 more sources