Results 101 to 110 of about 43,543 (282)

Domain motions of Argonaute, the catalytic engine of RNA interference

BMC Bioinformatics, 2007
Background The Argonaute protein is the core component of the RNA-induced silencing complex, playing the central role of cleaving the mRNA target. Visual inspection of static crystal structures already has enabled researchers to suggest conformational ...
Wall Michael E, Ming Dengming, Sanbonmatsu Kevin Y   +2 more
doaj   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity

The FEBS Journal, EarlyView.
A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina, Montserrat Ricart‐Fort, Rocío Díaz‐Parra, Sandra López‐Avilés, Tula Yance, Pablo Quirós, Elena Contreras, Ignasi Salaet, Sergio Atares, Rosa Aligué   +9 more
wiley   +1 more source

Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles

Children
Background: Argonautes (AGOs) are a type of protein that degrade specific messenger RNAs, consequently reducing the expression of a specific gene. These proteins consist of small, single-stranded RNA or DNA and may provide a route for detecting and ...
Zon-Min Lee, Hui-Chuan Chang, Shih-Feng Liu, Ying-Hsien Huang, Ho-Chang Kuo   +4 more
doaj   +1 more source

MicroRNA in control of gene expression: An overview of nuclear functions [PDF]

, 2016
The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the
Catalanotto, Caterina, Cogoni, Carlo, Zardo, Giuseppe   +2 more
core   +2 more sources

Adipose‐Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation

Obesity Reviews, EarlyView.
ABSTRACT Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population, widespread adoption of sedentary lifestyles, and
Michael Macleod, Joshua Price, Elpida Tsonou, David J. Baker, Kostas Tsintzas, Simon W. Jones   +5 more
wiley   +1 more source

Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination

Frontiers in Cell and Developmental Biology, 2020
The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several human ...
Madlen Müller, Madlen Müller, Francesco Fazi, Constance Ciaudo   +3 more
doaj   +1 more source

Suppression of Argonaute 2 Transcript Levels in Du182A Cells [PDF]

, 2018
RNA interference (RNAi) uses double-stranded RNA (dsRNA) molecules to degrade and suppress the transcript level of a complementary mRNA target1.
Featherston, Kyah, Schneck, Karen, Silver, Kristopher   +2 more
core  

Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells [PDF]

, 2019
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC).
Bellissimo, Teresa, Blandino, Giovanni, Calogero, Antonella, Cirenza, Mirko, De Angelis, Luciana, Di Martino, Giuseppe, Fatica, Alessandro, Fazi, Francesco, Fontemaggi, Giulia, Ganci, Federica, Masciarelli, Silvia, Petrozza, Vincenzo, Porta, Natale, Rosa, Paolo, Sacconi, Andrea, Sorci, Melissa, Tito, Claudia   +16 more
core   +2 more sources

Regulation of DNA Methylation in Peanut Leaves and Roots: Uncovering the Molecular Mechanisms for Increased Yield After Single‐Seed Sowing

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cytosine methylation is a crucial epigenetic modification that responds to various environmental cues, yet the specific mechanisms influencing planting patterns remain incompletely understood. This study reveals significant growth differences between single‐seed (SS) precision sowing and double‐seed (DS) sowing observed 42 days after ...
Shikai Fan, Jialei Zhang, Feng Guo, Fangji Xu, Zhaohui Tang, Rongchong Li, Bo Bai, Yiyang Liu, Guowei Li, Shubo Wan   +9 more
wiley   +1 more source