Results 11 to 20 of about 42,927 (266)
A Prokaryotic Twist on Argonaute Function [PDF]
Life, 2015 Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression.
Sarah Willkomm +3 more
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Knocking out the Argonautes [PDF]
Cell, 2006 Argonaute proteins are key players in gene silencing involving small RNAs. In this issue, Yigit et al. (2006) report a comprehensive study of Argonautes in the worm that places many of the 27 family members into a complex gene-silencing network.
Florian A. Steiner, Ronald H.A. Plasterk
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Argonaute and Argonaute-Bound Small RNAs in Stem Cells [PDF]
International Journal of Molecular Sciences, 2016 Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals.
Zhai, Lihong +7 more
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The Argonaute protein family [PDF]
Genome Biology, 2008 Argonaute proteins were first discovered genetically, and extensive research in the past few years has revealed that members of the Argonaute protein family are key players in gene-silencing pathways guided by small RNAs. Small RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs) or Piwi-interacting RNAs (piRNAs) are anchored into specific ...
Gunter Meister, Julia Höck
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Targeting Argonaute to chromatin [PDF]
Genes & Development, 2016 In many eukaryotes, siRNAs bound to Argonaute proteins guide chromatin-modifying enzymes to complementary loci, resulting in transcriptional gene silencing. Multiple lines of evidence indicate that siRNAs base-pair with longer RNAs produced at target loci, but the possibility that siRNAs base-pair directly with DNA remains an attractive hypothesis.
Jered M. Wendte +2 more
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Cold Spring Harbor Symposia on Quantitative Biology, 2006 RNA interference (RNAi) has been greatly exploited in recent years as an increasingly effective tool to study gene function by gene silencing. The introduction of exogenous double-stranded RNA (dsRNA) into a cell can trigger this gene silencing process.
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AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis
Plants, 2020 Small RNA (sRNA) turnover is a key but poorly understood mechanism that determines the homeostasis of sRNAs. Animal XRN genes contribute the degradation of sRNAs, AtXRN2 and AtXRN3 also contribute the pri-miRNA processing and miRNA loop degradation in ...
Yan Liu +7 more
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Expansion and Divergence of Argonaute Genes in the Oomycete Genus Phytophthora
Frontiers in Microbiology, 2018 Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the
Stephanie R. Bollmann +3 more
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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
eLife, 2021 Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear.
Gaspare La Rocca +19 more
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Molecular Cell, 2013 In this issue of Molecular Cell, De et al. (2013) report that highly complementary targets promote release of small RNAs from effector Argonaute complexes, thus providing mechanistic insights into regulation of small RNA stability and implications for siRNA design.
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