Results 11 to 20 of about 47,693 (305)
A Prokaryotic Twist on Argonaute Function [PDF]
Life, 2015 Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression.
Sarah Willkomm +3 more
doaj +3 more sources
Cell Research, 2023 Nicotinamide adenine dinucleotide (NAD^+) is a central metabolite in cellular processes. Depletion of NAD^+ has been demonstrated to be a prevalent theme in both prokaryotic and eukaryotic immune responses. Short prokaryotic Argonaute proteins (Agos) are
Xiaoshen Wang +13 more
semanticscholar +1 more source
Biomolecules, 2022 Prokaryotic Argonautes (pAgos) from mesophilic bacteria are attracting increasing attention for their genome editing potential. So far, it has been reported that KmAgo from Kurthia massiliensis can utilize DNA and RNA guide of any sequence to effectively
Xiaoman Jiang +3 more
doaj +1 more source
Understanding miRNA Based Gene Regulation in Parkinson’s Disease: An in silico Approach [PDF]
International Journal Bioautomation, 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by depletion or insufficient release of dopaminergic neurons in substantia nigra of the midbrain.
Surya Narayan Rath, Manorama Patri
doaj +1 more source
Anatomy of four human Argonaute proteins
Nucleic Acids Research, 2022 MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into Argonaute (AGO) proteins to form the effector complexes.
K. Nakanishi
semanticscholar +1 more source
Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
core +5 more sources
RNA-guided RNA silencing by an Asgard archaeal Argonaute
bioRxiv, 2023 Eukaryotic Argonaute proteins achieve gene repression and defense against viruses and transposons by RNA-guided RNA silencing. By contrast, known prokaryotic Argonautes adopt single-stranded DNA as guides and/or targets, leaving the evolutionary origin ...
Carolien Bastiaanssen +13 more
semanticscholar +1 more source
Knocking out the Argonautes [PDF]
Cell, 2006 Argonaute proteins are key players in gene silencing involving small RNAs. In this issue, Yigit et al. (2006) report a comprehensive study of Argonautes in the worm that places many of the 27 family members into a complex gene-silencing network.
Florian A. Steiner, Ronald H.A. Plasterk
openaire +3 more sources
bioRxiv, 2022 Argonaute (AGO) proteins associate with small RNAs to direct their effector function on complementary transcripts. The nematode C. elegans contains an expanded family of 19 functional AGO proteins, many of which have not been fully characterized. In this
Uri Seroussi +9 more
semanticscholar +1 more source
Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations
Nucleic Acids Research, 2021 Technological advances in rare DNA mutations detection have revolutionized the diagnosis and monitoring of tumors, but they are still limited by the lack of supersensitive and high-coverage procedures for identifying low-abundance mutations.
Qian Liu +17 more
semanticscholar +1 more source