Results 21 to 30 of about 25,854 (244)
MicroRNA-mediated gene silencing: are we close to a unifying model?
Biomolecular Concepts, 2012 MicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA).
James Victoria +2 more
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AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals
Frontiers in Bioscience-Landmark, 2020 Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex ...
Laura Sala +2 more
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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
eLife, 2021 Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear.
Gaspare La Rocca +19 more
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Expansion and Divergence of Argonaute Genes in the Oomycete Genus Phytophthora
Frontiers in Microbiology, 2018 Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the
Stephanie R. Bollmann +3 more
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A Prokaryotic Twist on Argonaute Function
Life, 2015 Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression.
Sarah Willkomm +3 more
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Are Argonaute-Associated Tiny RNAs Junk, Inferior miRNAs, or a New Type of Functional RNAs?
Frontiers in Molecular Biosciences, 2021 The biosynthesis pathways of microRNAs (miRNAs) have been well characterized with the identification of the required components. miRNAs are synthesized from the transcripts of miRNA genes and other RNAs, such as introns, transfer RNAs, ribosomal RNAs ...
Kotaro Nakanishi, Kotaro Nakanishi
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From transcription to translation: new insights in the structure and function of Argonaute protein
Biomolecular Concepts, 2012 Argonaute proteins play a central role in gene silencing pathways mediated by small RNA molecules. The ancestral function of small RNA-dependent silencing is related to genome protection against parasitic nucleic acids, such as transposons and viruses ...
Giorgi Corinna +2 more
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Non-Coding RNA, 2023 Aging in women is accompanied by a dramatic change in circulating sex steroid hormones. Specifically, the primary circulating estrogen, 17β-estradiol (E2), is nearly undetectable in post-menopausal women.
Megan L. Linscott +4 more
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Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes
Molecular Therapy: Nucleic Acids, 2018 MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs).
Yasuhiro Mie +6 more
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The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy
Molecular Therapy: Nucleic Acids, 2014 Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
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