Results 31 to 40 of about 47,693 (305)
Argonaute—a database for gene regulation by mammalian microRNAs
BMC Bioinformatics, 2005 BackgroundThe Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping.
Priyanka Shahi +9 more
semanticscholar +1 more source
Cold Spring Harbor Symposia on Quantitative Biology, 2006 RNA interference (RNAi) has been greatly exploited in recent years as an increasingly effective tool to study gene function by gene silencing. The introduction of exogenous double-stranded RNA (dsRNA) into a cell can trigger this gene silencing process.
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AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals
Frontiers in Bioscience-Landmark, 2020 Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex ...
Laura Sala +2 more
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Prokaryotic Argonaute Proteins as a Tool for Biotechnology
Molecular biology, 2022 Programmable nucleases are the most important tool for manipulating the genes and genomes of both prokaryotes and eukaryotes. Since the end of the 20th century, many approaches were developed for specific modification of the genome.
E. Kropocheva +5 more
semanticscholar +1 more source
Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
eLife, 2021 Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear.
Gaspare La Rocca +19 more
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Molecular Cell, 2013 In this issue of Molecular Cell, De et al. (2013) report that highly complementary targets promote release of small RNAs from effector Argonaute complexes, thus providing mechanistic insights into regulation of small RNA stability and implications for siRNA design.
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Characterization of the Small RNA Transcriptome of the Marine Coccolithophorid, Emiliania huxleyi [PDF]
, 2016 Small RNAs (smRNAs) control a variety of cellular processes by silencing target genes at the transcriptional or post-transcription level. While extensively studied in plants, relatively little is known about smRNAs and their targets in marine ...
Carrasco, Estela +7 more
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Innate Immunity Activation and RNAi Interplay in Citrus Exocortis Viroid—Tomato Pathosystem
Viruses, 2018 Although viroids are the smallest and simplest plant pathogens known, the molecular mechanisms underlying their pathogenesis remain unclear. To unravel these mechanisms, a dual approach was implemented consisting of in silico identification of potential ...
Thibaut Olivier, Claude Bragard
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A programmable omnipotent Argonaute nuclease from mesophilic bacteria Kurthia massiliensis
Nucleic Acids Research, 2021 Argonaute (Ago) proteins are conserved nucleic acid-guided proteins present in all domains of life. Eukaryotic Argonaute proteins (eAgos) are key players in RNA interference pathways and function as RNA-guided RNA endonucleases at physiological ...
Yang Liu +11 more
semanticscholar +1 more source
Frontiers in Plant Science, 2022 Plant argonautes (AGOs) play important roles in the defense responses against viruses. The expression of Nicotiana benthamiana AGO5 gene (NbAGO5) is highly induced by Bamboo mosaic virus (BaMV) infection; however, the underlying mechanisms remain elusive.
Yuan-Dun Ke +11 more
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