Results 41 to 50 of about 42,927 (266)

The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy

Molecular Therapy: Nucleic Acids, 2014
Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
doaj   +1 more source

Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]

, 2015
UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson, Le Pen, J?r?mie, Miska, Eric A., Sarkies, Peter, Tanguy, M?lanie   +4 more
core   +5 more sources

Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

Molecular Therapy: Nucleic Acids, 2018
MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs).
Yasuhiro Mie, Yu Hirano, Keiko Kowata, Akiyoshi Nakamura, Mayu Yasunaga, Yoshihiro Nakajima, Yasuo Komatsu   +6 more
doaj   +1 more source

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Cell Reports, 2017
In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing.
Jessica A. Hicks, Liande Li, Masayuki Matsui, Yongjun Chu, Oleg Volkov, Krystal C. Johnson, David R. Corey   +6 more
doaj   +1 more source

Modeling recursive RNA interference. [PDF]

, 2008
An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
A Dillin, A Grishok, A Reynolds, AA Andronow, AS Peek, C Gerner, CC Mello, CT Bergstrom, D Schmitter, DC Baulcombe, DW Bartlett, E Bernstein, E Koller, E Yang, FJ Isaacs, GL Tang, J Pak, J Yu, J Zhang, JC Arciero, JJ MacRae, JK Kim, John S. Mattick, JP Vert, K Ui-Tei, M Kaern, M Wiznerowicz, MAC Groenenbom, MC Saleh, MT McManus, MW Rhoades, N Bushati, N Doi, NR Dudley, NT Hoa, P Jia, Q Liu, S Dorner, SM Elbashir, SM Hammond, T Holen, T Sijen, T Tuschl, TA Vickers, TL Deans, U Alon, Wallace F. Marshall, X Darzacq, X Huang, XD Zhang, XS Ke, Y Tomari, Z Xie   +52 more
core   +5 more sources

Asymmetric expression of Argonautes in reproductive tissues [PDF]

Plant Physiology, 2021
The Arabidopsis genome encodes ten Argonautes proteins showing distinct expression pattern as well as intracellular localisation during sexual reproduction.
Olivier Voinnet, J A Schröder, Nathan Pumplin, Pauline E. Jullien, Pauline E. Jullien, Diane M. V. J. Bonnet   +5 more
openaire   +5 more sources

RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana

eLife, 2017
RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation.
Zhonghui Zhang, Fuqu Hu, Min Woo Sung, Chang Shu, Claudia Castillo-González, Hisashi Koiwa, Guiliang Tang, Martin Dickman, Pingwei Li, Xiuren Zhang   +9 more
doaj   +1 more source

microRNA-mediated regulation of microRNA machinery controls cell fate decisions

eLife, 2021
microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu, Mariah K Novak, Rachel M Pepin, Taylor Eich, Wenqian Hu   +4 more
doaj   +1 more source

Key Mechanistic Principles and Considerations Concerning RNA Interference

Frontiers in Plant Science, 2020
Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-specific RNA degradation induced by long double-stranded RNA (dsRNA).
Petr Svoboda
doaj   +1 more source

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

eLife, 2021
Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing.
Heesun Kim, Yue-He Ding, Gangming Zhang, Yong-Hong Yan, Darryl Conte Jr, Meng-Qiu Dong, Craig C Mello   +6 more
doaj   +1 more source