Results 51 to 60 of about 25,854 (244)

DNA recognition by an RNA-guided bacterial Argonaute. [PDF]

PLoS ONE, 2017
Argonaute (Ago) proteins are widespread in prokaryotes and eukaryotes and share a four-domain architecture capable of RNA- or DNA-guided nucleic acid recognition. Previous studies identified a prokaryotic Argonaute protein from the eubacterium Marinitoga
Kevin W Doxzen, Jennifer A Doudna
doaj   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, EarlyView.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity

The FEBS Journal, EarlyView.
A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina, Montserrat Ricart‐Fort, Rocío Díaz‐Parra, Sandra López‐Avilés, Tula Yance, Pablo Quirós, Elena Contreras, Ignasi Salaet, Sergio Atares, Rosa Aligué   +9 more
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Argonaute proteins: Structural features, functions and emerging roles

Journal of Advanced Research, 2020
Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing ...
Jin'en Wu, Jing Yang, William C. Cho, Yadong Zheng   +3 more
doaj   +1 more source

An Improved Description of the Small RNA Landscape of the Human Fungal Pathogen Aspergillus fumigatus

Molecular Microbiology, EarlyView.
The mechanisms of small RNA biogenesis in fungi are diverse and multifactorial. Here, we provide an improved understanding of the processing of double‐stranded RNA in the human fungal pathogen Aspergillus fumigatus, revealing susceptibility to high levels of double‐stranded RNA and limited input of the canonical RNAi machinery on the endogenous small ...
Xiaoqing Pan, Abdulrahman A. Kelani, Lukas Schrettenbrunner, Swatika Prabakar, Bhawana Israni, Matthew G. Blango   +5 more
wiley   +1 more source

Hybridity of mainly asexually propagating duckweeds in genus Lemna – dead end or breakthrough?

New Phytologist, EarlyView.
Summary The cosmopolitan, mainly vegetatively propagating, organ‐reduced monocotyledonous aquatic duckweeds are the smallest and fastest growing angiosperms, distributed world‐wide and flower rarely in nature. Recently, we reported intra‐ and interspecific hybrids and ploidy variants in the genus Lemna.
Yuri Lee, Luca Braglia, Anton Stepanenko, Jörg Fuchs, Veit Schubert, Silvia Gianì, Leone Ermes Romano, Giovanna Aronne, Chiara Forti, Ingo Schubert, Laura Morello   +10 more
wiley   +1 more source

Progress in micro RNA focused research in endocrinology

Endocrine Regulations, 2016
Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its ...
Voglova K., Bezakova J., Herichova Iveta
doaj   +1 more source

Domain motions of Argonaute, the catalytic engine of RNA interference

BMC Bioinformatics, 2007
Background The Argonaute protein is the core component of the RNA-induced silencing complex, playing the central role of cleaving the mRNA target. Visual inspection of static crystal structures already has enabled researchers to suggest conformational ...
Wall Michael E, Ming Dengming, Sanbonmatsu Kevin Y   +2 more
doaj   +1 more source