The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy
Molecular Therapy: Nucleic Acids, 2014 Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
doaj +1 more source
Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells [PDF]
, 2019 To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC).
Bellissimo, Teresa +16 more
core +2 more sources
Asymmetric expression of Argonautes in reproductive tissues [PDF]
Plant Physiology, 2021 The Arabidopsis genome encodes ten Argonautes proteins showing distinct expression pattern as well as intracellular localisation during sexual reproduction.
Olivier Voinnet +5 more
openaire +5 more sources
Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription
Cell Reports, 2017 In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing.
Jessica A. Hicks +6 more
doaj +1 more source
microRNA-mediated regulation of microRNA machinery controls cell fate decisions
eLife, 2021 microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu +4 more
doaj +1 more source
Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]
, 2010 Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas +8 more
core +1 more source
A structural view of microRNA-target recognition [PDF]
, 2016 It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity.
Leoni, Guido, Tramontano, Anna
core +1 more source
Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system
Nature CommunicationsShort prokaryotic Argonaute and Sir2 proteins function as an antivirus system. Here the authors describe structures of SPARSA (a heterodimer of Sir2-APAZ and prokaryotic Argonaute) with and without template DNA and guide RNA, providing structural basis ...
Xiangkai Zhen +9 more
semanticscholar +1 more source
Mammalian Argonaute-DNA binding? [PDF]
Biology Direct, 2014 When a field shares the consensus that a particular phenomenon does NOT occur, this may reflect extensive experimental investigations with negative outcomes, or may represent the "common sense" position based on current knowledge and established ways of thinking.
Octavio L A Gomes, Neil R. Smalheiser
openaire +3 more sources
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
eLife, 2021 Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing.
Heesun Kim +6 more
doaj +1 more source