Results 81 to 90 of about 25,854 (244)
Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments
Water and Environment Journal, EarlyView.Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze +3 more
wiley +1 more source
Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
Nature Communications, 2016 Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.
Tomohiro Miyoshi +3 more
doaj +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, Volume 13, Issue 3, 14 January 2026.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors
Advanced Science, Volume 13, Issue 4, 19 January 2026.RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao +7 more
wiley +1 more source
Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi
Nature Communications, 2017 While RNA interference is a highly conserved mechanism of gene regulation, how Argonaute-bound small RNAs are targeted for degradation is not well understood.
Paola Pisacane, Mario Halic
doaj +1 more source
Cancer Medicine, Volume 15, Issue 1, January 2026.ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo +2 more
wiley +1 more source
Argonaute bypasses cellular obstacles without hindrance during target search
Nature Communications, 2019 Argonaute protein is loaded with small RNA and scans long stretch of sequences to find complementary target sites. Here, using single-molecule FRET and kinetic modelling, the authors showed that prokaryotic Argonaute protein binds target DNA loosely and ...
Tao Ju Cui +6 more
doaj +1 more source
Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti.
PLoS ONE, 2012 RNA silencing, or RNA interference (RNAi) in metazoans mediates development, reduces viral infection and limits transposon mobility. RNA silencing involves 21-30 nucleotide RNAs classified into microRNA (miRNA), exogenous and endogenous small interfering
Scott A Bernhardt +5 more
doaj +1 more source
RNA Pol IV Plays Catch with Argonaute 4 [PDF]
, 2007 Susanne Till, Andreas G. Ladurner
openalex +1 more source