Results 81 to 90 of about 47,693 (305)
Digital Bioassays on the Slipchip Microfluidic Devices
Advanced Sensor Research, EarlyView.This review summarizes recent advances in SlipChip‐based digital bioassays, highlighting their simple “load and slip” operation for fluid partitioning which eliminate the need for sophisticated fluidic systems. Applications include digital nucleic acid analysis, digital protein analysis and single‐cell analysis, demonstrating the platform‘s potential ...
Qingqing Luo +5 more
wiley +1 more source
Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]
, 2010 A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan +7 more
core +1 more source
Argonaute Proteins Take Center Stage in Cancers
Cancers, 2021 Simple Summary The dysregulation of RNA interference (RNAi) has often been observed in cancers, where the main focus of research has been on the small RNA molecules directing RNAi.
I. Nowak, A. Sarshad
semanticscholar +1 more source
Advanced Science, EarlyView.METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang +8 more
wiley +1 more source
In Silico Identification, Phylogenetic and Bioinformatic Analysis of Argonaute Genes in Plants
International Journal of Genomics, 2014 Argonaute protein family is the key players in pathways of gene silencing and small regulatory RNAs in different organisms. Argonaute proteins can bind small noncoding RNAs and control protein synthesis, affect messenger RNA stability, and even ...
Khaled Mirzaei +3 more
doaj +1 more source
Lost and Found: Piwi and Argonaute Pathways in Flatworms
Frontiers in Cellular and Infection Microbiology, 2021 Platyhelminthes comprise one of the major phyla of invertebrate animals, inhabiting a wide range of ecosystems, and one of the most successful in adapting to parasitic life.
Santiago Fontenla +2 more
doaj +1 more source
An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum
Advanced Science, EarlyView.This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang +11 more
wiley +1 more source
Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis
eLife, 2016 Small RNAs are central players in RNA silencing, yet their cytoplasmic compartmentalization and the effects it may have on their activities have not been studied at the genomic scale.
Shengben Li +13 more
doaj +1 more source
Beyond BLASTing : ribonucleoprotein evolution via structural prediction and ancestral sequence reconstruction [PDF]
, 2016 Primary homology in DNA and protein sequence has long been used to infer a relationship between similar sequences. However gene sequence, and thus protein sequence, can change over time.
Daly, Toni K
core
New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]
, 2012 Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson +55 more
core +3 more sources