Results 101 to 110 of about 2,680,652 (283)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating the Effect of Argument-Driven Inquiry in Laboratory Instruction

, 2019
The aim of this study is to investigate the effect of argument-driven inquiry (ADI) based laboratory instruction on the academic achievement, argumentativeness, science process skills, and argumentation levels of pre-service science teachers in the General Physics Laboratory III class. The study was conducted with 79 pre-service science teachers.
Tuba Demircioğlu, Sedat Ucar
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pengaruh Model Pembelajaran Argument-Driven Inquiry Terhadap Keterampilan Argumentasi Siswa [PDF]

, 2018
This study aims to determine the significance of the influence of the use of Argument-Driven Inquiry (ADI) learning models, students' academic abilities, and the interaction between learning models and academic abilities towards student argumentation ...
Hasnunidah, Neni, Sikumbang, Darlen, Ningtyas, Ninda   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Inquiry research trends through bibliometric analysis (2020-2023)

Biosfer
This article aims to analyze the trend of Inquiry research through bibliometrics in the Google schoolar database from 2020 to 2023. The article consists of a total of 993 articles, then sorted into 788 suitable articles and analyzed.
Lilis Lismaya, Wiyanto Wiyanto, Saiful Ridlo   +2 more
doaj   +1 more source

Impact of STEM-Integrated Argument-Driven Inquiry on Developing Scientific Argumentation in Indonesian Middle Schools

Jurnal Penelitian Pendidikan IPA
This study explores the effectiveness of integrating Argument-Driven Inquiry (ADI) with Science, Technology, Engineering, and Mathematics (STEM) education to improve high school students' argumentation skills on the topic of the human respiratory system.
Hasnunidah, Neni, Meriza, Nadya, Fadhila, Sherly, Rosidin, Undang   +3 more
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

MODEL ARGUMENT DRIVEN INQUIRY (ADI) DENGAN MEMANFAATKAN GAMIFIKASI UNTUK MENINGKATKAN PENALARAN ILMIAH SISWA [PDF]

Penelitian ini bertujuan untuk menerapkan penerapan model Argument Driven Inquiry dengan gamifikasi berbasis website wordwall dalam meningkatkan penalaran ilmiah siswa pada materi fluida statis.
Mulvia, Rahmadhani, Saadah, Fitrotus, Muhajir, Siti Nurdianti   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source