Results 61 to 70 of about 2,680,652 (283)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
PENERAPAN ARGUMENT DRIVEN INQUIRY (ADI) BERBANTUAN ARGUMENT MAPPING TERHADAP PENINGKATAN KETERAMPILAN ARGUMENTASI SISWA PADA MATERI SISTEM EKSKRESI MANUSIA [PDF]
Keterampilan abad-21 sangat dibutuhkan peserta didik saat ini dikarenakan tuntutan perkembangan zaman baik teknologi ataupun informasi yang semakin berkembang pesat.
LUBNAA FAAIQOH,
core +1 more source
Kalamatika, 2017 This study is designed in the form of experiment with the design of control group and posttest only aimed at investigating the role of learning that Argument Driven Inquiry (ADI) in improving senior high school students’ creative mathematical reasoning ...
Wahyu Hidayat
doaj +1 more source
JPBI (Jurnal Pendidikan Biologi Indonesia), 2023 Post-pandemic policies encourage teachers and students to carry out learning in offline, where they used to go online before. One learning strategy that can be applied in this condition is blended learning, which combines the advantages of offline and ...
Dea Yuliyanti +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Bartın Üniversitesi Eğitim Fakültesi Dergisi, 2018 The purpose of the present study was to investigate whether pre-service teachers’ cognitive and affective expectations were met after participation of lab investigations that were designed based on the ADI instructional model. Based on Novak’ theory of learning, when the students get responsibilities to connect new knowledge with existing one, the ...
Pınar Seda Çetin, Guluzar Eymur
openaire +4 more sources