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Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan [PDF]
Frontiers in EndocrinologyThe aged population, expected to double by 2050, makes up a large proportion of people living with metabolic disease. Obesity rates in the elderly are rapidly increasing, with estimates that nearly 40% of men and women over the age of 60 are classified ...
Angel A. Lee +3 more
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Reproduction, 2001 Aromatase is the enzyme complex that catalyses the synthesis of oestrogens from androgens, and therefore it has unique potential to influence the physiological balance between the sex steroid hormones. Both aromatase cytochrome P450 (P450arom) and NADPH-cytochrome P450 reductase (reductase), the two essential components of the enzyme complex, are ...
A, Conley, M, Hinshelwood
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The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Animals, 2021 Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol.
Luigi Rosati +4 more
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Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]
PLoS ONE, 2017 Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata +6 more
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Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. [PDF]
PLoS ONE, 2009 Immunohistochemistry is one of the most suitable methods for the detection of intratumoral aromatase in order to identify patients who may respond to aromatase inhibitor therapy in hormone-dependent breast cancer.
Yanyan Hong +7 more
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Quantitative analysis of long-form aromatase mRNA in the male and female rat brain. [PDF]
PLoS ONE, 2014 In vitro studies show that estrogens acutely modulate synaptic function in both sexes. These acute effects may be mediated in vivo by estrogens synthesized within the brain, which could fluctuate more rapidly than circulating estrogens.
Nino Tabatadze +2 more
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Frontiers in Oncology, 2022 Treatment of patients with castration-resistant prostate cancer (CRPC) remains a major clinical challenge. We previously showed that estrogenic effects contribute to CRPC progression and are primarily caused by the increased endogenous estradiol produced
Qimei Lin +11 more
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Aromatase, aromatase inhibitors, and breast cancer [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 Estrogens are known to be important in the growth of breast cancers in both pre and postmenopausal women. As the number of breast cancer patients increases with age, the majority of breast cancer patients are postmenopausal women. Although estrogens are no longer made in the ovaries after menopause, peripheral tissues produce sufficient concentrations ...
Saranya, Chumsri +4 more
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Biology, 2023 The enzyme aromatase is expressed at high levels in the ventromedial hypothalamic nucleus (VMN), a principal component of the brain gluco-regulatory network.
Karen P. Briski +4 more
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Estrogens: a new player in spermatogenesis.
Folia Histochemica et Cytobiologica, 2008 The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them, estrogens are the end products obtained from the irreversible transformation of androgens by aromatase.
Camille Bois +5 more
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