Results 11 to 20 of about 44,670 (231)
BJS (British Journal of Surgery), EarlyView., 2020 This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund +4 more
wiley +1 more source
Computational method for aromatase-related proteins using machine learning approach.
PLoS ONE, 2023 Human aromatase enzyme is a microsomal cytochrome P450 and catalyzes aromatization of androgens into estrogens during steroidogenesis. For breast cancer therapy, third-generation aromatase inhibitors (AIs) have proven to be effective; however patients ...
Muthu Krishnan Selvaraj, Jasmeet Kaur
doaj +1 more source
Potential utility of natural products as regulators of breast cancer-associated aromatase promoters
Reproductive Biology and Endocrinology, 2011 Aromatase, the key enzyme in estrogen biosynthesis, converts androstenedione to estrone and testosterone to estradiol. The enzyme is expressed in various tissues such as ovary, placenta, bone, brain, skin, and adipose tissue.
Walker Larry A +4 more
doaj +1 more source
The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue
Regulatory Mechanisms in Biosystems, 2018 Pathogenesis and clinical manifestations of metabolic syndrome (and other conditions characterized by the growth of fat mass and decreased adiponectin content) is associated with an imbalance of sex hormones, which develops under the influence of ...
D. V. Lytkin +2 more
doaj +1 more source
Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner
Frontiers in Neuroscience, 2020 The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals.
Nelly Alia-Klein +8 more
doaj +1 more source
PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs
Scientific Reports, 2021 Aromatase is an estrogen synthetic enzyme that plays important roles in brain functions. To quantify aromatase expression in the brain by positron emission tomography (PET), we had previously developed [11C]cetrozole, which showed high specificity and ...
Kayo Takahashi +9 more
doaj +1 more source
Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses
Frontiers in Molecular Neuroscience, 2018 Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay +4 more
doaj +1 more source
BMC Cancer, 2009 Background New, third-generation aromatase inhibitors (AIs) have proven comparable or superior to the anti-estrogen tamoxifen for treatment of estrogen receptor (ER) and/or progesterone receptor (PR) positive breast cancer.
Lykkesfeldt Anne E +7 more
doaj +1 more source
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus
European Journal of Histochemistry, 2020 The goal of this study was to evaluate P450 aromatase localization in the epididymis of two different vertebrates: the lizard Podarcis sicula, a seasonal breeder, and Rattus rattus, a continuous breeder.
Luigi Rosati +4 more
doaj +1 more source
Estrogens and male reproduction: a new concept
Brazilian Journal of Medical and Biological Research, 2007 The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them estrogens are the end products obtained from the irreversible transformation of androgens by a microsomal enzymatic complex named aromatase ...
S. Carreau +7 more
doaj +1 more source