Results 21 to 30 of about 44,670 (231)

Does GPER1 Play a Role in Sexual Dimorphism?

Frontiers in Endocrinology, 2020
Estrogens are critical in driving sex-typical social behaviours that are ethologically relevant in mammals. This is due to both production of local estrogens and signaling by these ligands, particularly in an interconnected set of nuclei called the ...
Janine L. Dovey, Nandini Vasudevan
doaj   +1 more source

Aromatase: a neuroprotective enzyme [PDF]

Progress in Neurobiology, 2003
Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme catalyzes the conversion of testosterone and other C19 steroids to estradiol. Genetic or pharmacological inhibition
L. M. Garcia Segura, S. Veiga, A. Sierra, R. C. Melcangi, I. Azcoitia   +4 more
openaire   +4 more sources

Gene Expression and Epigenetic Modification of Aromatase during Sex Reversal and Gonadal Development in Blotched Snakehead (Channa maculata)

Fishes, 2023
The cyp19a1 gene codes aromatase that converts androgen to estrogen, which plays a central role in early female differentiation and ovarian development in teleosts.
Sujing Huang, Yuxia Wu, Kunci Chen, Xiaotian Zhang, Jian Zhao, Qing Luo, Haiyang Liu, Fang Wang, Kaibin Li, Shuzhan Fei, Xincheng Zhang, Mi Ou   +11 more
doaj   +1 more source

Low Testosterone in Men With Type 2 Diabetes: The Role of Estrogen Excess and Aromatase Activity. [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Objective Low testosterone is common in men with type 2 diabetes and is associated with adverse metabolic outcomes. Our objective was to identify factors associated with low total and calculated free testosterone (CFT) in men with type 2 diabetes, with a focus on relative estrogen excess and subcutaneous adipose aromatase expression.
Tun NNZ, Livingstone DEW, Gibb FW.
europepmc   +2 more sources

Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

Neural Plasticity, 2016
Numerous studies show that 17β-estradiol (E2) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is
Janine Prange-Kiel, Danuta A. Dudzinski, Felicitas Pröls, Markus Glatzel, Jakob Matschke, Gabriele M. Rune   +5 more
doaj   +1 more source

Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice

Biology, 2023
17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models.
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann   +6 more
doaj   +1 more source

Medial Amygdalar Aromatase Neurons Regulate Aggression in Both Sexes

Cell Reports, 2015
Aromatase-expressing neuroendocrine neurons in the vertebrate male brain synthesize estradiol from circulating testosterone. This locally produced estradiol controls neural circuits underlying courtship vocalization, mating, aggression, and territory ...
Elizabeth K. Unger, Kenneth J. Burke Jr., Cindy F. Yang, Kevin J. Bender, Patrick M. Fuller, Nirao M. Shah   +5 more
doaj   +1 more source

Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

Metabolites, 2023
The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an ...
Alaa Edris, Mohammed Abdelrahman, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Elrashied A. E. Garelnabi, Sabrin R. M. Ibrahim, Rawan Bafail, Waad A. Samman, Kholoud F. Ghazawi, Gamal A. Mohamed, Abdulrahim A. Alzain   +11 more
doaj   +1 more source

Locally Advanced Breast Cancer Patient’s Recurrence Rates Comparison Received Steroidal and Nonsteroidal Aromatase Inhibitor Based on Luminal

Biomolecular and Health Science Journal
Introduction: Aromatase inhibitors are hormonal therapies used in menopausal breast cancer with positive progesterone receptors and/or estrogen receptors.
Desak Gede Agung Suprabawati, Bernadeta Hernik Setiyandari, Dwi Hari Susilo, Bara Kharisma, Rizki Amalia   +4 more
doaj   +1 more source

Hormonal Homologies between Canine Mammary Cancer and Human Breast Cancer in a Series of Cases

Veterinary Sciences, 2022
The validity of spontaneous canine mammary cancer (CMC) as a natural model for the study of human breast cancer (HBC) from a hormonal point of view has never been thoroughly investigated.
Paloma Jimena de Andrés, Sara Cáceres, Juan Carlos Illera, Belén Crespo, Gema Silván, Felisbina Luisa Queiroga, Maria José Illera, Maria Dolores Pérez-Alenza, Laura Peña   +8 more
doaj   +1 more source