Results 51 to 60 of about 44,670 (231)
Drug Testing and Analysis, EarlyView.The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker +3 more
wiley +1 more source
Rescue of Pressure Overload‐Induced Heart Failure by Estrogen Therapy
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Andrea Iorga +12 more
doaj +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?
Frontiers in Neuroscience, 2018 The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic development resulting in the establishment of six discrete cortical layers.
Matthew C. S. Denley +4 more
doaj +1 more source
Aromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence? [PDF]
International Journal of Fertility and Sterility, 2016 Orally active aromatase inhibitors (AIs) have gained attention for treatment of infertile women with endometriosis in whom aromatase p450 is aberrantly expressed.
Hatem Abu Hashim
doaj +1 more source
Food Bioengineering, EarlyView.Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source
Head &Neck, EarlyView.ABSTRACT Background Cutaneous adnexal carcinomas are a very rare group of cancers arising from appendageal structures of the skin. More than half occur in the head and neck region. No standard treatments exist for metastatic disease. Methods A 48‐year‐old postmenopausal female presented with an enlarging scalp lesion.
Nilesh Kapoor +3 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Peter A. Fasching +20 more
wiley +1 more source
Interactions of aromatase and seladin-1: A neurosteroidogenic and gender perspective
Translational Neuroscience, 2019 Aromatase and seladin-1 are enzymes that have major roles in estrogen synthesis and are important in both brain physiology and pathology. Aromatase is the key enzyme that catalyzes estrogen biosynthesis from androgen precursors and regulates the brain’s ...
Kelicen-Ugur Pelin +3 more
doaj +1 more source
Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons
Frontiers in Integrative Neuroscience, 2019 Estrogen status is a significant risk factor in the development of temporomandibular joint disorders (TMD). Classically, estrogen status is thought to derive mainly from ovarian sources; however, it is well known that estradiol (E2) also is synthesized ...
David A. Bereiter +2 more
doaj +1 more source