Results 61 to 70 of about 44,670 (231)

Human Aromatase Deficiency

, 2019
Fil: Saraco, Nora Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P.
Guercio, Gabriela Viviana, Saraco, Nora Isabel, Costanzo, Mariana, Marino, Roxana Marcela, Belgorosky, Alicia   +4 more
openaire   +2 more sources

Long‐term benefit from adjuvant tamoxifen therapy for ER+ HER2− breast cancer by PR positivity

International Journal of Cancer, EarlyView.
What's New? Tamoxifen is a cornerstone of endocrine therapy for estrogen receptor (ER)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer. Its long‐term benefits, however, may vary by progesterone receptor (PR) status. Here, using data from the Stockholm tamoxifen trials, the authors evaluated whether PR expression predicts
Anna E. Nordenskjöld, Magdalena Ríos‐Romero, Huma Dar, Tommy Fornander, Gizeh Perez‐Tenorio, Helena Fohlin, Olle Stål, Julia Tutzauer, Linda S. Lindström   +8 more
wiley   +1 more source

Protective Effects of Hesperidin on Letrozole-Induced Neurotoxicity: Involvement of Oxidative Stress, Apoptotic Signaling, and Inflammation. [PDF]

J Biochem Mol Toxicol
Letrozole induces neurotoxicity by promoting oxidative stress, inflammation, and apoptotic signaling in the brain. Hesperidin co‐treatment mitigates these effects by restoring redox balance, suppressing pro‐inflammatory cytokines, and normalizing Bax/Bcl‐2–mediated apoptotic pathways, thereby exerting neuroprotective effects.
Ayhan İ, Kaplan MN, Kasim DD, Ozmen O, Ciftci O.   +4 more
europepmc   +2 more sources

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Optimizing outcomes in intrauterine insemination: A narrative synthesis of two decades of clinical research (2000–2024)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Intrauterine insemination (IUI) is a widely used first‐line fertility treatment, yet its success rates vary considerably. This review synthesizes evidence from peer‐reviewed studies published between 2000 and 2024, including randomized controlled trials, cohort and case–control studies, as well as systematic and narrative reviews identified ...
Kasuni Akalanka
wiley   +1 more source

Inverse association between obesity and intestinal endometriosis: Findings from a cross‐sectional study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluates the association between obesity and the presence of bowel endometriosis in patients undergoing surgery. Methods A retrospective cross‐sectional observational study was conducted with patients treated between September 2023 and December 2024, at a specialized endometriosis outpatient clinic of a tertiary hospital ...
Tereza Carolina Fonseca Corrêa, Marco Aurelio Pinho Oliveira   +1 more
wiley   +1 more source

Post‐Radiation Granuloma Annulare: A Series of Three Cases

JEADV Clinical Practice, EarlyView.
ABSTRACT We report typical cases of biopsy confirmed granuloma annulare occurring on irradiated skin in the context of breast cancer in three women in their seventies. The lesions appeared immediately after start of irradiation in one patient, 4 and 15 months after the end of radiation treatment in the other two. The lesions eventually spread elsewhere
Léa Scheid, Mona Mitcov, Dan Lipsker
wiley   +1 more source

Risk Factors Associated With the Number of Symptoms and Distress Caused by Genitourinary Syndrome of Menopause in Taiwanese Women

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT A high percentage of women who undergo the transition to postmenopause experience both menopausal symptoms and genitourinary syndrome of menopause (GSM). However, GSM is often underdiagnosed. This research aims to identify risk factors that may influence the number of GSM symptoms and whether they cause distress in Taiwanese women > 45 years ...
Shu‐Fang Su, Chiu‐Lin Wang, Shu‐Yuan Lin   +2 more
wiley   +1 more source

Association Between Preoperative Dyslipidemia and the Prognosis of Patients With Endometrial Cancer: A Retrospective Cohort Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Endometrial cancer (EC) is closely related to metabolic disorders. We aimed to investigate whether preoperative dyslipidemia independently affects the prognosis of patients with EC. One hundred and ninety‐four women diagnosed with EC by pathology and who had undergone standardized surgical treatment at the Affiliated Hospital of Jining Medical
Song Li, Rong‐He Sun, Qing Chen, Zeng‐Shu Huang, Yun‐Fei Wang, Chang‐Zhong Li   +5 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source