Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]
PLoS ONE, 2015 In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde +2 more
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Endocrinology and the brain: Corticotropin-Releasing Hormone signaling [PDF]
, 2017 Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Armando, Natalia Giannina +3 more
core +2 more sources
Arrestins: structural disorder creates rich functionality
Protein & Cell, 2018 Arrestins are soluble relatively small 44–46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners.
Vsevolod V. Gurevich +2 more
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Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination [PDF]
Biochemistry, 2011 Numerous mutations in E3 ubiquitin ligase parkin were shown to associate with familial Parkinson's disease. Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmunoprecipitation of endogenous proteins from brain tissue and shown to be direct using purified proteins ...
M Rafiuddin, Ahmed +5 more
openaire +2 more sources
Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6 [PDF]
, 2003 PURPOSE: To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. METHODS: 7G6 immunocytochemistry was performed on sections of human, primate, and bovine retina.
Baehr, Wolfgang +6 more
core +2 more sources
To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors
International Journal of Translational MedicineG protein-coupled receptors (GPCRs) are the largest family of diverse receptors in eukaryotic organisms, playing a critical role in modulating human physiology. It therefore comes as no surprise that about 36% of all currently available drugs target this
Nikitas G. Liolitsas +2 more
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Lack of beta-arrestin signaling in the absence of active G proteins
Nature Communications, 2018 Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable
Manuel Grundmann +23 more
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Neurobiology of Disease, 2011 Alterations of multiple G protein-mediated signaling pathways are detected in schizophrenia. G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions ...
E.R. Bychkov +4 more
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β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. [PDF]
PLoS ONE, 2013 Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2.
Elie Simard +5 more
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Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling
eLife, 2022 β-Arrestins are master regulators of cellular signaling that operate by desensitizing ligand-activated G-protein-coupled receptors (GPCRs) at the plasma membrane and promoting their subsequent endocytosis.
Benjamin Barsi-Rhyne +2 more
doaj +1 more source