Results 11 to 20 of about 7,063 (180)

Chloroquine inhibits artificial oocyte activation induced by ethanol or Sr²⁺ but not by sperm in mice. [PDF]

J Reprod Dev
Calcium release from the endoplasmic reticulum via sperm-derived phospholipase C zeta is crucial for oocyte activation during fertilization. Chloroquine (CQ) inhibits the increase in cytoplasmic calcium.
Yamazaki T, Bari MW, Kishigami S.
europepmc   +4 more sources

Efficacy of Artificial Oocyte Activation in Improving the Reproductive Outcome in Poor Responders: A Single Centre Cohort Study. [PDF]

J Family Reprod Health, 2023
Objective: Achieving pregnancy in poor ovarian response patients is a challenge. Failed fertilization after ICSI, despite normal semen parameters is due to defects in oocyte activation.
Kaur B, Malik S, Prakash V, Bhatia V, Gupta D.   +4 more
europepmc   +2 more sources

Artificial oocyte activation using Ca²⁺ ionophores following intracytoplasmic sperm injection for low fertilization rate. [PDF]

Front Endocrinol (Lausanne), 2023
This large multi-center retrospective study examined whether artificial oocyte activation (AOA) using Ca2+ ionophore following ICSI improves the live birth rate for couples with previous ICSI cycles of unexplained low fertilization rate.
Akashi K, Yamada M, Jwa SC, Utsuno H, Kamijo S, Hirota Y, Tanaka M, Osuga Y, Kuji N.   +8 more
europepmc   +2 more sources

Artificial oocyte activation with Ca²⁺ ionophore improves reproductive outcomes in patients with fertilization failure and poor embryo development in previous ICSI cycles. [PDF]

Front Endocrinol (Lausanne), 2023
Research questionDoes artificial oocyte activation (AOA) by a calcium ionophore (ionomycin) improve the previous fertilization failure or poor embryo development of intracytoplasmic sperm injection (ICSI) account for male factor infertility or other ...
Ruan JL, Liang SS, Pan JP, Chen ZQ, Teng XM.   +4 more
europepmc   +2 more sources

Embryo development and live birth resulted from artificial oocyte activation after microdissection testicular sperm extraction with ICSI in patients with non-obstructive azoospermia. [PDF]

Front Endocrinol (Lausanne), 2023
IntroductionThe application of microdissection testicular sperm extraction (micro-TESE) to retrieve the sperm of patients with non-obstructive azoospermia (NOA) has greatly increased. Patients with NOA often have poor quality sperm.
Zhang X, Li L, Zhang W, Luo Y, Mao Y, Du H, Li L.   +6 more
europepmc   +2 more sources

DNA methylation and gene expression changes in mouse pre- and post-implantation embryos generated by intracytoplasmic sperm injection with artificial oocyte activation. [PDF]

Reprod Biol Endocrinol, 2021
Background The application of artificial oocyte activation (AOA) after intracytoplasmic sperm injection (ICSI) is successful in mitigating fertilization failure problems in assisted reproductive technology (ART).
Yin M, Yu W, Li W, Zhu Q, Long H, Kong P, Lyu Q.   +6 more
europepmc   +2 more sources

Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations. [PDF]

EMBO Mol Med
Oocyte activation is essential for successful fertilization and subsequent embryonic development. However, only a few disease-causing genes have been associated with sperm-derived oocyte activation failure, and the underlying molecular mechanisms and ...
Gan S, Gan S, Li Y, Yin L, Yang X, Lou C, Li S, Lin M, Li X, Xu W, Zhou J, Hu P, Yao Z, Yuan Y, Sheng J, Zhang C, Yang W, Li Y, Huang H.   +18 more
europepmc   +2 more sources

Effect of Epidermal Growth Factor and 6-Dimethylaminopurine on In Vitro Maturation and Artificial Activation of Spix's Yellow-Toothed Cavy (<i>Galea spixii</i> Wagler, 1831) Oocytes. [PDF]

Animals (Basel)
The successful application of assisted reproductive technologies (ARTs), such as in vitro maturation (IVM) and artificial oocyte activation, requires species-specific adaptations. Although these methods are routinely used in laboratory rodents, their use
Aquino LVC, Olindo SL, Silva YLF, Silva VD, Oliveira LRM, Oliveira MF, Pereira AF.   +6 more
europepmc   +2 more sources

Live birth following an innovative artificial oocyte activation protocol using double calcium stimulators. [PDF]

Chin Med J (Engl), 2023
Gao Y, Yang D, Fang Y, Wang X, Li D.
europepmc   +2 more sources

Functional Roles of Src Kinase Activity in Oocyte Maturation and Artificial Egg Activation in <i>Xenopus laevis</i>. [PDF]

Cells
Src family tyrosine kinases regulate oocyte maturation and fertilization in many species, yet their physiological roles in Xenopus laevis (X. laevis) remain incompletely defined. Here, we generated three X. laevis Src (xSrc) constructs with defined point
Sato KI, Tokmakov AA.
europepmc   +2 more sources