Results 11 to 20 of about 7,154 (227)
Development of artificial ribonucleases [PDF]
Pure and Applied Chemistry, 1998 Abstract
Robert Häner +3 more
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Synthesis and Antiviral Activity of Bis-Histidyl Diaminoalkanes in Relation to Feline calicivirus
Антибиотики и Химиотерапия, 2020 An RNA-containing virus of the Vesivirus genus Caliciviridae family causes feline calicivirosis, a disease widely spread worldwide. The literature describes a systemic form of infection leading to the death of up to 60% of sick animals (FCV-VSD).
L. S. Koroleva +5 more
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Development of Site-specific Artificial Ribonucleases [PDF]
Nucleic Acids Symposium Series, 2007 Recently we found that an antisense 2'-O-methyloligonucleotide, with two terpyridine*Cu(II) complexes at contiguous internal sites, was highly active as a site-specific (sequence-specific) artificial ribonuclease, with the activity derived from the cooperative action of the complexes.
Hiroshi, Takayama +3 more
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Molecules, 2020 The RNA cleaving catalyst tris(2-aminobenzimidazole) when attached to the 5’ terminus of oligonucleotides cuts complementary RNA strands in a highly site-specific manner.
Felix Zellmann, Michael W. Göbel
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Molecules, 2017 In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt)
Merita Murtola +3 more
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Site-selective artificial ribonuclease using pinpoint RNA activation [PDF]
Nucleic Acids Symposium Series, 2001 An acridine residue attached to the end or the inside of a DNA activates the target phosphodiester linkages in complementary RNA. Due to this pinpoint activation, the RNA is site-selectively and efficiently cleaved at these linkages by various free metal ions under mild condition.
A, Kuzuya, R, Mizoguchi, M, Komiyama
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Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes
Molecules, 2019 Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge
Olivia Luige +3 more
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Target-directed catalytic metallodrugs
Brazilian Journal of Medical and Biological Research, 2013 Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets.
J.C. Joyner, J.A. Cowan
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Anticancer Activity of Reconstituted Ribonuclease S‐Decorated Artificial Viral Capsid
ChemBioChem, 2022 AbstractRibonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S‐decorated artificial viral capsids with a size of 70–170 nm by self‐assembly of the β‐annulus‐S‐peptide followed by ...
Yingbing Liang +4 more
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Identification and analysis of S-genotypes in 23 new pear cultivars [PDF]
Guoshu xuebao[Objective] Taxonomically, pear (Pyrus spp.) belongs to the Rosaceae family, Maloideae subfamily and Pyrus genus. It exhibits a typical gametophytic self-incompatibility (GSI) mechanism controlled by a single S-locus with multiple alleles.
WANG Yanan +5 more
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