Results 11 to 20 of about 2,480 (127)
A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer [PDF]
Journal of NanobiotechnologyEsophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens.
Xue Zheng +4 more
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Molecular Therapy: Nucleic Acids, 2022 Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments.
Daniel Meraviglia-Crivelli +6 more
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A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy. [PDF]
PLoS ONE, 2015 AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major side ...
Thu Le Trinh +7 more
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AS1411-functionalized delivery nanosystems for targeted cancer therapy
Exploration of Medicine, 2021 Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications ...
Pooria Safarzadeh Kozani +2 more
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Progress in cancer drug delivery based on AS1411 oriented nanomaterials
Journal of Nanobiotechnology, 2022 Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer ...
Xin Tong, Lu Ga, Jun Ai, Yong Wang
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Pharmaceutics, 2021 The nucleolin-binding G-quadruplex AS1411 aptamer has been widely used for cancer therapy and diagnosis and linked to nanoparticles for its selective targeting activity.
Giulia Vindigni +6 more
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Aptamer AS1411-functionalized gold nanoparticle-melittin complex for targeting MCF-7 breast cancer cell line [PDF]
Nanomedicine Journal, 2022 Objective(s): Several studies reported the apoptotic and lytic activity of melittin (Mel) in different tumor cells. In this study, a novel nano-complex was developed composed of AS1411aptamers, melittin and gold nanoparticle for the treatment of breast ...
Payam Bayat +6 more
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Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles
Radiation Oncology, 2021 Background Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor cells, while having small effect ...
Somayeh Sadat Mehrnia +4 more
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Di-san junyi daxue xuebao, 2020 Objective To prepare a novel nanoparticle carrying iron(Ⅱ) phthalocyanine (FePc) coupled with aptamer AS1411 for targeting human breast cancer MCF-7 cells and evaluate its physicochemical properties, targeting ability to MCF-7 cells, photoacoustic ...
HE Yubei +7 more
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Aptamer-modified carbon dots for enhancement of photodynamic therapy of cancer cells
Talanta Open, 2022 Carbon dots (CDs) have emerged as promising materials for photodynamic therapy (PDT) because of their intriguing photochemical properties, high stability, and low toxicity.
Menghui Ma +6 more
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