Results 11 to 20 of about 2,541 (157)
AS1411-functionalized delivery nanosystems for targeted cancer therapy [PDF]
Exploration of Medicine, 2021 Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications ...
Pooria Safarzadeh Kozani +2 more
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Progress in cancer drug delivery based on AS1411 oriented nanomaterials [PDF]
Journal of Nanobiotechnology, 2022 Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer ...
Xin Tong, Lu Ga, Jun Ai, Yong Wang
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Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.
PLoS ONE, 2020 Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered.
Emily M Murphy +4 more
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Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles [PDF]
Radiation Oncology, 2021 Background Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor cells, while having small effect ...
Somayeh Sadat Mehrnia +4 more
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Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14.
PLoS ONE, 2016 Aptamers are small synthetic oligonucleotides that bind to target proteins with high specificity and affinity. AS1411 is an aptamer that binds to nucleolin, which is overexpressed in the cytoplasm and occurs on the surface of cancer cells.
Yuri Cho +11 more
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The anti-tumor effect of chinese medicine extracts camptothecin -AS1411 system
Pharmacological Research - Modern Chinese MedicineIntroduction: The AS1411 aptamer has shown great potential in the development of targeted anti-tumor drug delivery systems. Camptothecin (CPT, Xǐshù Jiǎn), a cytotoxic quinoline alkaloid first isolated from the traditional Chinese medicine Camptotheca ...
Zhanbiao He +4 more
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A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy. [PDF]
PLoS ONE, 2015 AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major side ...
Thu Le Trinh +7 more
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Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411 [PDF]
Scientific Reports, 2016 AbstractAptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2′-deoxyinosine in AS1411, an anti-proliferative G-rich oligodeoxynucleotide aptamer, which binds selectively to the nucleolin protein.
Xinmeng Fan +4 more
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Pharmaceutics, 2021 The nucleolin-binding G-quadruplex AS1411 aptamer has been widely used for cancer therapy and diagnosis and linked to nanoparticles for its selective targeting activity.
Giulia Vindigni +6 more
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Aptamer AS1411-functionalized gold nanoparticle-melittin complex for targeting MCF-7 breast cancer cell line [PDF]
Nanomedicine Journal, 2022 Objective(s): Several studies reported the apoptotic and lytic activity of melittin (Mel) in different tumor cells. In this study, a novel nano-complex was developed composed of AS1411aptamers, melittin and gold nanoparticle for the treatment of breast ...
Payam Bayat +6 more
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