Results 41 to 50 of about 2,480 (127)
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae +6 more
wiley +1 more source
From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment
Cell Proliferation, EarlyView.Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang +9 more
wiley +1 more source
Development of Electrochemical Aptasensor for Label-Free Glioma Cell Detection
International Journal of Electrochemical Science, 2017 This work explored the fabrication of a functionalized graphene-and-aptamer AS1411-based electrochemical sensor to achieve tag-free cancer cell determination. The proposed electrochemical aptasensor could distinguish between normal cells and glioma cells
Xianjun Zhao +2 more
doaj +1 more source
Pharmaceutics, 2021 Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma.
Anca N. Cadinoiu +5 more
doaj +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2021 Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer therapy. Among vascular coagulation agents, the extracellular domain of coagulation-inducing protein tissue factor, truncated tissue factor (tTF), is the most ...
Bozhao Li +9 more
doaj +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, Volume 13, Issue 36, 29 June 2026.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Journal of Nanobiotechnology, 2021 Background Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, targeted, and safe delivery systems that
Yuming Yang +12 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang +8 more
wiley +1 more source
Journal of Nanobiotechnology, 2023 Targeted chemo-phototherapy has received widespread attention in cancer treatment for its advantages in reducing the side effects of chemotherapeutics and improving therapeutic effects.
Mengyue Li +9 more
doaj +1 more source