Results 31 to 40 of about 2,541 (157)

Intracellular Monitoring of AS1411 Aptamer by Time-Resolved Microspectrofluorimetry and Fluorescence Imaging [PDF]

Journal of Fluorescence, 2015
Time-resolved microspectrofluorimetry and fluorescence microscopy imaging-two complementary fluorescence techniques-provide important information about the intracellular distribution, level of uptake and binding/interactions inside living cell of the labeled molecule of interest.
Bok, Jiří, Bonneau, Stéphanie, Kočišová, Eva, Praus, Petr, Sureau, Franck   +4 more
openaire   +3 more sources

Nucleolin recognizing silica nanoparticles inhibit cell proliferation by activating the Bax/Bcl-2/caspase-3 signalling pathway to induce apoptosis in liver cancer

Frontiers in Pharmacology, 2023
Multifunctional nanocarrier platforms have shown great potential for the diagnosis and treatment of liver cancer. Here, a novel nucleolin-responsive nanoparticle platform was constructed for the concurrent detection of nucleolin and treatment of liver ...
Liangliang Xiang, Yun Li, Xinyu Gu, Shujie Li, Junwei Li, Jinlong Li, Yongxiang Yi   +6 more
doaj   +1 more source

Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities

Vaccines, 2017
Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy in ...
Peter Mastrangelo, Michael J. Norris, Wenming Duan, Edward G. Barrett, Theo J. Moraes, Richard G. Hegele   +5 more
doaj   +1 more source

Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer

Medical Sciences Forum, 2022
Conventional anticancer therapies present low specificity, leading to several secondary effects. To improve these drawbacks, aptamers able to fold into G-quadruplex (G4) are being used to promote drug accumulation in cancer cells.
Jéssica Lopes-Nunes, Paula A. Oliveira, Carla Cruz   +2 more
doaj   +1 more source

AS1411-conjugated gold nanospheres and their potential for breast cancer therapy

Oncotarget, 2015
AS1411 is a quadruplex-forming DNA oligonucleotide that functions as an aptamer to target nucleolin, a protein present on the surface of cancer cells. Clinical trials of AS1411 have indicated it is well tolerated with evidence of therapeutic activity, but improved pharmacology and potency may be required for optimal efficacy.
Mohammad T, Malik, Martin G, O'Toole, Lavona K, Casson, Shelia D, Thomas, Gina T, Bardi, Elsa Merit, Reyes-Reyes, Chin K, Ng, Kyung A, Kang, Paula J, Bates   +8 more
openaire   +3 more sources

Aptamer-Functionalized Iron-Based Metal–Organic Frameworks (MOFs) for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

Molecules, 2022
Hypoxia-activated prodrugs (HAPs) with selective toxicity in tumor hypoxic microenvironments are a new strategy for tumor treatment with fewer side effects.
Xuan Wang, Qing Chen, Congxiao Lu
doaj   +1 more source

Carbon Dots-AS1411 Aptamer Nanoconjugate for Ultrasensitive Spectrofluorometric Detection of Cancer Cells [PDF]

Scientific Reports, 2017
AbstractIn the present study, a sensitive and selective signal-on method for aptamer based spectrofluorometric detection of cancer cells is introduced. AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells.
Hasan Motaghi, Masoud Ayatollahi Mehrgardi, Philippe Bouvet   +2 more
openaire   +2 more sources

Aptamer-programmable adeno-associated viral vectors as a novel platform for cell-specific gene transfer

Molecular Therapy: Nucleic Acids, 2023
Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue.
Francesco Puzzo, Chuanling Zhang, Bethany Powell Gray, Feijie Zhang, Bruce A. Sullenger, Mark A. Kay   +5 more
doaj   +1 more source

AS1411-functionalized albumin nanoparticles for nucleolin-targeted realgar delivery and therapy in triple-negative breast cancer

Frontiers in Pharmacology
Realgar (As4S4) has shown antitumor activity, but its pharmaceutical application is limited by poor aqueous solubility, low bioavailability, and systemic toxicity. In this study, we developed AS1411-functionalized albumin nanoparticles (As4S4@ BSA-AS1411
Liping Dong, Liping Dong, Wenzhuo Ran, Yanqiong Li, Lixia Yang, Xi Zhou   +5 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source