Results 21 to 30 of about 2,541 (157)
Synthesis and Evaluation of AS1411-Lenalidomide-Targeted Degradation Chimera in Antitumor Therapy. [PDF]
Pharmaceuticals (Basel)Background: High expression of nucleolin (NCL) on the surface of tumor cells is closely associated with disease progression and poor prognosis. The aptamer–PROTAC conjugate (APC) technology provides a novel molecular design strategy for the targeted degradation of NCL.
Ma X +11 more
europepmc +3 more sources
Di-san junyi daxue xuebao, 2020 Objective To prepare a novel nanoparticle carrying iron(Ⅱ) phthalocyanine (FePc) coupled with aptamer AS1411 for targeting human breast cancer MCF-7 cells and evaluate its physicochemical properties, targeting ability to MCF-7 cells, photoacoustic ...
HE Yubei +7 more
doaj +1 more source
Aptamer-modified carbon dots for enhancement of photodynamic therapy of cancer cells
Talanta Open, 2022 Carbon dots (CDs) have emerged as promising materials for photodynamic therapy (PDT) because of their intriguing photochemical properties, high stability, and low toxicity.
Menghui Ma +6 more
doaj +1 more source
Anti-Proliferative Effect of Doxorubicin-Loaded AS1411 Aptamer on Colorectal Cancer Cell [PDF]
Asian Pacific Journal of Cancer Prevention, 2021 Doxorubicin (Dox) inhibits DNA replication and causes DNA damage resulting in cell death. It is a common drug for treatment of many cancers. Treatment efficacy and side effects of Dox are critical issues in using it because the drug lacks of specificity. The objective of this study was to improve the specificity of Dox by the incorporation of this drug
Lohlamoh, Walaiporn +2 more
openaire +2 more sources
Computable structured aptamer for targeted treatment of ovarian cancer
Frontiers in Genetics, 2023 Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin.
Luoshan Ruan +8 more
doaj +1 more source
Biomedicines, 2022 Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving as anti-nucleolin aptamers, have been reported to inhibit the proliferation and induce
Naoki Nohira +5 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To establish a simple and rapid method for detecting tumor cells based on multivalent aptamers. Methods Rolling circle amplification was used to form a long single stranded DNA scaffold with repeat sequences of poly T, then the obtained product
XU Jieru +4 more
doaj +1 more source
PLoS ONE, 2016 AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers.
Ye Cheng +8 more
doaj +1 more source
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer [PDF]
Experimental and Molecular Pathology, 2009 Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or intramolecularly to form four stranded or "quadruplex" structures, which have unusual biophysical and biological properties. Several synthetic G-rich quadruplex-forming oligodeoxynucleotides have recently been investigated as therapeutic agents for various human ...
Paula J, Bates +4 more
openaire +2 more sources
Pharmaceutics, 2022 DNA is an excellent programmable polymer for the generation of self-assembled multivalent nanostructures useful for biomedical applications. Herein, we developed (i) folate-functionalized nanocages (Fol-NC), very efficiently internalized by tumor cells ...
Valeria Unida +5 more
doaj +1 more source