Results 21 to 30 of about 2,480 (127)
Computable structured aptamer for targeted treatment of ovarian cancer
Frontiers in Genetics, 2023 Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin.
Luoshan Ruan +8 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To establish a simple and rapid method for detecting tumor cells based on multivalent aptamers. Methods Rolling circle amplification was used to form a long single stranded DNA scaffold with repeat sequences of poly T, then the obtained product
XU Jieru +4 more
doaj +1 more source
Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14.
PLoS ONE, 2016 Aptamers are small synthetic oligonucleotides that bind to target proteins with high specificity and affinity. AS1411 is an aptamer that binds to nucleolin, which is overexpressed in the cytoplasm and occurs on the surface of cancer cells.
Yuri Cho +11 more
doaj +1 more source
Biomedicines, 2022 Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving as anti-nucleolin aptamers, have been reported to inhibit the proliferation and induce
Naoki Nohira +5 more
doaj +1 more source
PLoS ONE, 2016 AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers.
Ye Cheng +8 more
doaj +1 more source
Pharmaceutics, 2022 DNA is an excellent programmable polymer for the generation of self-assembled multivalent nanostructures useful for biomedical applications. Herein, we developed (i) folate-functionalized nanocages (Fol-NC), very efficiently internalized by tumor cells ...
Valeria Unida +5 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Multifunctional nanocarrier platforms have shown great potential for the diagnosis and treatment of liver cancer. Here, a novel nucleolin-responsive nanoparticle platform was constructed for the concurrent detection of nucleolin and treatment of liver ...
Liangliang Xiang +6 more
doaj +1 more source
Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities
Vaccines, 2017 Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy in ...
Peter Mastrangelo +5 more
doaj +1 more source
Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.
PLoS ONE, 2020 Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered.
Emily M Murphy +4 more
doaj +1 more source
Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer
Medical Sciences Forum, 2022 Conventional anticancer therapies present low specificity, leading to several secondary effects. To improve these drawbacks, aptamers able to fold into G-quadruplex (G4) are being used to promote drug accumulation in cancer cells.
Jéssica Lopes-Nunes +2 more
doaj +1 more source