Results 21 to 30 of about 2,544 (153)
Molecular Therapy: Nucleic Acids, 2022 Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments.
Daniel Meraviglia-Crivelli +6 more
doaj +1 more source
Aptamer-modified carbon dots for enhancement of photodynamic therapy of cancer cells
Talanta Open, 2022 Carbon dots (CDs) have emerged as promising materials for photodynamic therapy (PDT) because of their intriguing photochemical properties, high stability, and low toxicity.
Menghui Ma +6 more
doaj +1 more source
Carbon Dots-AS1411 Aptamer Nanoconjugate for Ultrasensitive Spectrofluorometric Detection of Cancer Cells. [PDF]
Sci Rep, 2017 International audienceIn the present study, a sensitive and selective signal-on method for aptamer based spectrofluorometric detection of cancer cells is introduced.
Motaghi H, Mehrgardi MA, Bouvet P.
europepmc +2 more sources
Frontiers in Pharmacology, 2023 Multifunctional nanocarrier platforms have shown great potential for the diagnosis and treatment of liver cancer. Here, a novel nucleolin-responsive nanoparticle platform was constructed for the concurrent detection of nucleolin and treatment of liver ...
Liangliang Xiang +6 more
doaj +1 more source
Molecules, 2022 Hypoxia-activated prodrugs (HAPs) with selective toxicity in tumor hypoxic microenvironments are a new strategy for tumor treatment with fewer side effects.
Xuan Wang, Qing Chen, Congxiao Lu
doaj +1 more source
Nucleolin-Targeting AS1411 Aptamer-Conjugated Nanospheres for Targeted Treatment of Glioblastoma. [PDF]
PharmaceuticsPost-operative chemotherapy is still required for the treatment of glioblastoma (GBM), for which nanocarrier-based drug delivery has been identified as one of the most effective methods. However, the blood-brain barrier (BBB) and non-specific delivery to
Seo K +5 more
europepmc +2 more sources
, 2023 Background: Combination therapy has attracted tremendous interest for its great potential in treating cancers. Materials & methods: Based on chitosan-coated silver nanotriangles, polyethylene glycol, AS1411 aptamer and doxorubicin, a multifunctional ...
Xuechun Kan (16912300) +6 more
core +1 more source
Anti-nucleolin aptamer AS1411: an advancing therapeutic
Frontiers in Molecular Biosciences, 2023 Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Alexander Van den Avont +1 more
doaj +1 more source
Computable structured aptamer for targeted treatment of ovarian cancer
Frontiers in Genetics, 2023 Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin.
Luoshan Ruan +8 more
doaj +1 more source
DataSheet1_Anti-nucleolin aptamer AS1411: an advancing therapeutic.PDF
, 2023 Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Alexander Van den Avont (17017158) +3 more
core +1 more source