Results 31 to 40 of about 2,544 (153)
Pharmaceutics, 2021 Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma.
Anca N. Cadinoiu +5 more
doaj +1 more source
Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer
Medical Sciences Forum, 2022 Conventional anticancer therapies present low specificity, leading to several secondary effects. To improve these drawbacks, aptamers able to fold into G-quadruplex (G4) are being used to promote drug accumulation in cancer cells.
Jéssica Lopes-Nunes +2 more
doaj +1 more source
DataSheet1_Insights into the binding mode of AS1411 aptamer to nucleolin.docx
, 2022 AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin overexpressed in cancer cells, however, little is known about their binding process.
Fuze Jiang (2573305) +5 more
core +1 more source
AS1411-functionalized delivery nanosystems for targeted cancer therapy
Exploration of Medicine, 2021 Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications ...
Pooria Safarzadeh Kozani +2 more
doaj +1 more source
Interaction study of Dox-incorporated AS1411 aptamer and nucleolin by molecular dynamics simulation
, 2023 AS1411 aptamer is able to recognise the nucleolin overexpressed on cancer cell membranes and has shown promise as a carrier of doxorubicin (Dox) to the cells. This study aimed to study the interaction between nucleolin and aptamers, in either the absence
Yuthana Tantirungrotechai (1429801) +4 more
core +1 more source
, 2022 Aptamer-functionalized Ce4+-ion-modified C-dots act as catalytic hybrid systems, aptananozymes, catalyzing the H2O2 oxidation of dopamine. A series of aptananozymes functionalized with different configurations of the dopamine binding aptamer, DBA, are ...
Pu Zhang (51027) +9 more
core +1 more source
Biosensors and Bioelectronics: X, 2023 The detection of Circulating Tumor Cells (CTCs) is of profound importance for cancer diagnosis and monitoring in diseased patients. In the presented work, an aptasensor for CTC detection was developed using AS1411 aptamer specific for nucleolin on cancer
Rajshree Gupta +3 more
doaj +1 more source
Development of Electrochemical Aptasensor for Label-Free Glioma Cell Detection
International Journal of Electrochemical Science, 2017 This work explored the fabrication of a functionalized graphene-and-aptamer AS1411-based electrochemical sensor to achieve tag-free cancer cell determination. The proposed electrochemical aptasensor could distinguish between normal cells and glioma cells
Xianjun Zhao +2 more
doaj +1 more source
, 2022 Polyadenine-stabilized Au nanoparticles (pA-AuNPs) reveal dual nanozyme catalytic activities toward the H2O2-mediated oxidation of dopamine to aminochrome and toward the aerobic oxidation of glucose to gluconic acid and H2O2.
Pu Zhang (51027) +10 more
core +1 more source
AS1411-aptamer suppresses hepatocellular carcinoma by up-regulating galectin-14.
, 2016 (A) DNA microarray results (volume plot of expression level, hierarchical clustering analysis) (B) Induction of LGALS-14 by the AS1411-aptamer was confirmed by RT-PCR under normoxic (20% O2 and 5% CO2 at 37°C) and hypoxic conditions (1% O2, 5% CO2, and ...
Su Jong Yu (313985) +11 more
core +1 more source