Results 31 to 40 of about 2,325 (152)
Pharmaceutics, 2021 Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma.
Anca N. Cadinoiu +5 more
doaj +1 more source
Biomedicine & Pharmacotherapy, 2022 Severe side effects of chemotherapy agents on vital organs are the major causes of cancer-related mortality, not merely cancer disease. Encapsulating chemotherapeutic molecules in nanocarriers is a justifiable solution in decreasing the risk of their side effects and boosting the efficiency of treatment. The present study has developed the doxorubicin (
Nashmin Fayazi, Hosseini +5 more
openaire +2 more sources
AS1411-functionalized delivery nanosystems for targeted cancer therapy
Exploration of Medicine, 2021 Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications ...
Pooria Safarzadeh Kozani +2 more
doaj +1 more source
Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer
Medical Sciences Forum, 2022 Conventional anticancer therapies present low specificity, leading to several secondary effects. To improve these drawbacks, aptamers able to fold into G-quadruplex (G4) are being used to promote drug accumulation in cancer cells.
Jéssica Lopes-Nunes +2 more
doaj +1 more source
Biosensors and Bioelectronics: X, 2023 The detection of Circulating Tumor Cells (CTCs) is of profound importance for cancer diagnosis and monitoring in diseased patients. In the presented work, an aptasensor for CTC detection was developed using AS1411 aptamer specific for nucleolin on cancer
Rajshree Gupta +3 more
doaj +1 more source
PLoS ONE, 2016 AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers.
Ye Cheng +8 more
doaj +1 more source
Development of Electrochemical Aptasensor for Label-Free Glioma Cell Detection
International Journal of Electrochemical Science, 2017 This work explored the fabrication of a functionalized graphene-and-aptamer AS1411-based electrochemical sensor to achieve tag-free cancer cell determination. The proposed electrochemical aptasensor could distinguish between normal cells and glioma cells
Xianjun Zhao +2 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To prepare a novel nanoparticle carrying iron(Ⅱ) phthalocyanine (FePc) coupled with aptamer AS1411 for targeting human breast cancer MCF-7 cells and evaluate its physicochemical properties, targeting ability to MCF-7 cells, photoacoustic ...
HE Yubei +7 more
doaj +1 more source
Pharmaceutics, 2022 DNA is an excellent programmable polymer for the generation of self-assembled multivalent nanostructures useful for biomedical applications. Herein, we developed (i) folate-functionalized nanocages (Fol-NC), very efficiently internalized by tumor cells ...
Valeria Unida +5 more
doaj +1 more source
Fluorescent Polymer-AS1411-Aptamer Probe for dSTORM Super-Resolution Imaging of Endogenous Nucleolin
Biomacromolecules, 2022 Nucleolin is a multifunctional protein involved in essential biological processes. To precisely localize it and unravel its different roles in cells, fluorescence imaging is a powerful tool, especially super-resolution techniques. Here, we developed polymer-aptamer probes, both small and bright, adapted to direct stochastic optical reconstruction ...
Laura Fabre +8 more
openaire +3 more sources