Results 51 to 60 of about 2,544 (153)
The mechanism of AS1411-or modified AS1411-aptamersregarding anti-tumor effects in SNU-761 cells.
, 2016 (A) No significant induction of SNU-761 cell apoptosis was noted with AS1411- or modified AS1411-aptamers. Immunoblot analysis was performed using anti-caspase 9, anti-caspase 8, anti-caspase 7 and anti-actin antibodies.
Su Jong Yu (313985) +11 more
core +1 more source
A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer
Journal of NanobiotechnologyEsophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens.
Xue Zheng +4 more
doaj +1 more source
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae +6 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2021 Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer therapy. Among vascular coagulation agents, the extracellular domain of coagulation-inducing protein tissue factor, truncated tissue factor (tTF), is the most ...
Bozhao Li +9 more
doaj +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.
PLoS ONE, 2020 Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered.
Emily M Murphy +4 more
doaj +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, Volume 13, Issue 36, 29 June 2026.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Novel bispecific aptamer targeting PD-1 and nucleolin for cancer immunotherapy
Cancer Nanotechnology, 2023 Background Immune checkpoint blockade (ICB) is a promising strategy for cancer treatment and has achieved remarkable clinical results. Further improvement of ICB efficacy may advance cancer immunotherapy and has evident medical importance.
Junjun Fu +5 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang +8 more
wiley +1 more source
, 2019 It has been reported that PIWI-interacting RNAs (piRNAs) play critical roles in activating invasion and metastasis, evading growth suppressors, and sustaining proliferative signaling of cancer and can be regarded as a novel biomarker candidate.
Wenjie Ma (435202) +7 more
core +1 more source