Results 71 to 80 of about 2,325 (152)

AS1411 Aptamer Conjugated Gelatin-Siloxane Nanoparticles for targeted siRNA delivery

, 2017
RNA interference (RNAi) has potential advantages over other gene therapy approaches due to its high specificity and the ability to inhibit target gene expression. Thus, developing a stable, safe, effective siRNA delivery system is necessary to achieve targeted therapy.
Xueqin Zhao, Sijie Tao, Yongming Zhang, Dajin Wang, Lei Ren   +4 more
openaire   +1 more source

Preparation of AS1411 Aptamer Modified Mn-MoS2 QDs for Targeted MR Imaging and Fluorescence Labelling of Renal Cell Carcinoma

International Journal of Nanomedicine, 2019
Shaohui Zheng,1–3,* Min Zhang,2,* Hongyan Bai,2 Meijuan He,2 Lina Dong,2 Lulu Cai,2 Mingming Zhao,2 Qi Wang,2 Kai Xu,1–3 Jingjing Li1–3 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, People ...
Zheng S, Zhang M, Bai H, He M, Dong L, Cai L, Zhao M, Wang Q, Xu K, Li J   +9 more
doaj  

Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411.

PLoS ONE, 2017
Cancer stem cells represent the putative tumor-driving subpopulation thought to account for drug resistance, relapse, and metastatic spread of epithelial and other cancer types.
Sif Holmboe, Pernille Lund Hansen, Helge Thisgaard, Ines Block, Carolin Müller, Niels Langkjær, Poul Flemming Høilund-Carlsen, Birgitte Brinkmann Olsen, Jan Mollenhauer   +8 more
doaj   +1 more source

An intelligent poly aptamer-encoded DNA nanoclew for tumor site activated mitochondria-targeted photodynamic therapy and MR imaging

Materials Today Bio
Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most promising antitumor therapies, as it significantly enhances the efficacy of photosensitizers. An efficient and biocompatible nanocarrier to deliver cationic photosensitizers (
Minghui Chen, Hanbo Xu, Pengzhao Chang, Xueqi Li, Shuang Liu, Lingyue Xu, Kai Xu, Guohui Cheng   +7 more
doaj   +1 more source

The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell

International Journal of Antimicrobial Agents, 2016
AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates ...
PERRONE, ROSALBA, BUTOVSKAYA, ELENA, LAGO, SARA, GARZINO DEMO, ALFREDO, Pannecouque, Christophe, PALU', GIORGIO, RICHTER, SARA   +6 more
openaire   +2 more sources

Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake

Heliyon
Anti-nucleolin (NCL) aptamer AS1411 is the first anticancer aptamer tested in clinical trials. Gold nanoparticles (AuNP) have been widely exploited for various biomedical applications due to their unique functional properties. In this study, we evaluated
Dalya Saidi, Marya Obeidat, Shrouq Alsotari, Abed-Alqader Ibrahim, Rula Al-Buqain, Suha Wehaibi, Dana A. Alqudah, Hamdi Nsairat, Walhan Alshaer, Alaaldin M. Alkilany   +9 more
doaj   +1 more source

Targeted delivery of doxorubicin to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers

Expert Opinion on Drug Delivery, 2018
Objectives: Here, a novel cruciform DNA nanostructure was developed for targeted delivery of doxorubicin (Dox), as an anticancer agent, to lung (A549 cells) and breast (4T1 cells) cancer cells. The cruciform DNA nanostructure consisted of AS1411 aptamer as targeting agent and Forkhead Box Protein M1(FOXM1) aptamer as therapeutic agent.
Khalil Abnous, Noor Mohammad Danesh, Mohammad Ramezani, Fahimeh Charbgoo, Amirhossein Bahreyni, Seyed Mohammad Taghdisi   +5 more
openaire   +2 more sources

The anti-tumor effect of chinese medicine extracts camptothecin -AS1411 system

Pharmacological Research - Modern Chinese Medicine
Introduction: The AS1411 aptamer has shown great potential in the development of targeted anti-tumor drug delivery systems. Camptothecin (CPT, Xǐshù Jiǎn), a cytotoxic quinoline alkaloid first isolated from the traditional Chinese medicine Camptotheca ...
Zhanbiao He, Zhen Wang, Lu Ga, Jun Ai, Xin Tong   +4 more
doaj   +1 more source

Oxygen-producing and pH-responsive targeted DNA nanoflowers for enhanced chemo-sonodynamic therapy of lung cancer

Materials Today Bio
Lung cancer is the deadliest kind of cancer in the world, and the hypoxic tumor microenvironment can significantly lower the sensitivity of chemotherapeutic drugs and limit the efficacy of different therapeutic approaches.
Hongjian Liao, Yuchao Cao, Can Hu, Shangfeng Shen, Zhifei Zhang, Dairong Li, Yonghong Du   +6 more
doaj   +1 more source

A pH-Sensitive I-Motif Aptamer Probe for Dual Targeting and Imaging of Pancreatic Cancer Cells via Nucleolin Interactions

Journal of Bio-X Research
This study investigates the targeted imaging and tumor inhibition effects of a “signal-off” imaging-based activatable aptamer probe (I-AAP) for pancreatic cancer.
Quwen Li, Qingquan Chen, Juan Tang, Qicai Liu, Feng Gao   +4 more
doaj   +1 more source