Results 61 to 70 of about 2,544 (153)
ChemMedChem, Volume 21, Issue 9, 14 May 2026.From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk +1 more
wiley +1 more source
Results in ChemistryMultivalent interactions enhance targeted drug delivery by enabling stronger, specific binding to overexpressed receptors on target cells. This multivalent approach improves targeting efficiency, increases local drug concentration, and reduces off-target
Kanpitcha Jiramitmongkon +4 more
doaj +1 more source
Small Science, Volume 6, Issue 5, May 2026.Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani +5 more
wiley +1 more source
Anti-tumor effects of modified AS1411-aptamers on SNU-761 cells.
, 2016 (A) Significant cytotoxic effects on SNU-761 cells were noted with modified AS1411-aptamer treatment under both normoxic and hypoxic conditions. (B) Cell cycle analysis revealed that modified AS1411-aptamer significantly decreased the proportion of S ...
Su Jong Yu (313985) +11 more
core +1 more source
Recent Advances in Tetrahedral Framework Nucleic Acids for Multimodal Synergistic Cancer Therapy
Aggregate, Volume 7, Issue 4, April 2026.This review summarizes recent advances in tFNA‐based multimodal cancer therapy, including structural features, delivery strategies, and therapeutic regimens addressing key challenges in cancer treatment. We outline design principles, address translational hurdles, and highlight intelligent response and immune regulation as promising directions to ...
Zishan Huang +7 more
wiley +1 more source
In silico activity of AS1411 aptamer against nucleolin of cancer cells
, 2020 Background: It has been expected that AS1411 aptamer could work against the cancer cells. Although the general information is available, there is still lack of details for the purpose.
Farahbakhsh, Z. +4 more
core
Novel nanosized AS1411–chitosan–BODIPY conjugate for molecular fluorescent imaging
International Journal of Nanomedicine, 2019 Setareh Taki,1 Mehdi Shafiee Ardestani21Department of Radiopharmacy, International Campus, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences ...
Taki S, Ardestani MS
doaj
Advanced Functional Materials, Volume 36, Issue 25, 26 March 2026.Fluorescent nanodiamonds (fNDs) have emerged as an invaluable quantum sensing platform for biological and biochemical systems. This paper investigates the influence of common surface functionalization strategies for bioconjugation on the quantum properties of nitrogen vacancy (NV) centers in nanodiamonds.
Anja Sadžak +6 more
wiley +1 more source
, 2018 In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy.
Haghjooy Javanmard, Shaghayegh +11 more
core +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin +6 more
wiley +1 more source