Results 61 to 70 of about 2,325 (152)
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, Volume 13, Issue 36, 29 June 2026.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Results in ChemistryMultivalent interactions enhance targeted drug delivery by enabling stronger, specific binding to overexpressed receptors on target cells. This multivalent approach improves targeting efficiency, increases local drug concentration, and reduces off-target
Kanpitcha Jiramitmongkon +4 more
doaj +1 more source
BMEMat, Volume 4, Issue 2, June 2026.This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam +4 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang +8 more
wiley +1 more source
Novel nanosized AS1411–chitosan–BODIPY conjugate for molecular fluorescent imaging
International Journal of Nanomedicine, 2019 Setareh Taki,1 Mehdi Shafiee Ardestani21Department of Radiopharmacy, International Campus, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences ...
Taki S, Ardestani MS
doaj
ChemMedChem, Volume 21, Issue 9, 14 May 2026.From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk +1 more
wiley +1 more source
Frontiers in PharmacologyRealgar (As4S4) has shown antitumor activity, but its pharmaceutical application is limited by poor aqueous solubility, low bioavailability, and systemic toxicity. In this study, we developed AS1411-functionalized albumin nanoparticles (As4S4@ BSA-AS1411
Liping Dong +5 more
doaj +1 more source
Small Science, Volume 6, Issue 5, May 2026.Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani +5 more
wiley +1 more source
Recent Advances in Tetrahedral Framework Nucleic Acids for Multimodal Synergistic Cancer Therapy
Aggregate, Volume 7, Issue 4, April 2026.This review summarizes recent advances in tFNA‐based multimodal cancer therapy, including structural features, delivery strategies, and therapeutic regimens addressing key challenges in cancer treatment. We outline design principles, address translational hurdles, and highlight intelligent response and immune regulation as promising directions to ...
Zishan Huang +7 more
wiley +1 more source
Advanced Functional Materials, Volume 36, Issue 25, 26 March 2026.Fluorescent nanodiamonds (fNDs) have emerged as an invaluable quantum sensing platform for biological and biochemical systems. This paper investigates the influence of common surface functionalization strategies for bioconjugation on the quantum properties of nitrogen vacancy (NV) centers in nanodiamonds.
Anja Sadžak +6 more
wiley +1 more source