Results 81 to 90 of about 2,544 (153)

Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake

Heliyon
Anti-nucleolin (NCL) aptamer AS1411 is the first anticancer aptamer tested in clinical trials. Gold nanoparticles (AuNP) have been widely exploited for various biomedical applications due to their unique functional properties. In this study, we evaluated
Dalya Saidi, Marya Obeidat, Shrouq Alsotari, Abed-Alqader Ibrahim, Rula Al-Buqain, Suha Wehaibi, Dana A. Alqudah, Hamdi Nsairat, Walhan Alshaer, Alaaldin M. Alkilany   +9 more
doaj   +1 more source

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

, 2016
AS1411 is a g-quadruplex-forming aptamer capable of selectively entering cancer cells by nucleolin receptor-mediated uptake. In this study, we investigated the cell internalization properties and plasticity of AS1411 carrying different locked nucleic ...
Nguyen, Chi-Hung, Smith, C I Edvard, Landras-Guetta, Corinne, Lundin, Karin E, Zaghloul, Eman M, Gissberg, Olof, Wengel, Jesper, Zain, Rula   +7 more
core   +1 more source

The anti-tumor effect of chinese medicine extracts camptothecin -AS1411 system

Pharmacological Research - Modern Chinese Medicine
Introduction: The AS1411 aptamer has shown great potential in the development of targeted anti-tumor drug delivery systems. Camptothecin (CPT, Xǐshù Jiǎn), a cytotoxic quinoline alkaloid first isolated from the traditional Chinese medicine Camptotheca ...
Zhanbiao He, Zhen Wang, Lu Ga, Jun Ai, Xin Tong   +4 more
doaj   +1 more source

Anti-Proliferative Effect of Doxorubicin-Loaded AS1411 Aptamer on Colorectal Cancer Cell. [PDF]

Asian Pac J Cancer Prev, 2021
Lohlamoh W, Soontornworajit B, Rotkrua P.   +2 more
europepmc   +1 more source

Aptamer-Functionalized and Backbone Redox-Responsive Hyperbranched Polymer for Targeted Drug Delivery in Cancer Therapy

, 2016
A novel type of backbone redox-responsive hyperbranched poly­(2-((2-(acryloyloxy)­ethyl)­disulfanyl)­ethyl 4-cyano-4-(((propylthio)­carbonothioyl)-thio)-pentanoate-co-poly­(ethylene glycol) methacrylate) (HPAEG) has been designed and prepared ...
Yuanyuan Zhuang (1821550), Dannong He (386180), Lin He (102807), Gangsheng Tong (1315152), Hongping Deng (1544353), Yue Su (180932), Ruibin Wang (1959997), Xinyuan Zhu (1315158)   +7 more
core   +1 more source

Oxygen-producing and pH-responsive targeted DNA nanoflowers for enhanced chemo-sonodynamic therapy of lung cancer

Materials Today Bio
Lung cancer is the deadliest kind of cancer in the world, and the hypoxic tumor microenvironment can significantly lower the sensitivity of chemotherapeutic drugs and limit the efficacy of different therapeutic approaches.
Hongjian Liao, Yuchao Cao, Can Hu, Shangfeng Shen, Zhifei Zhang, Dairong Li, Yonghong Du   +6 more
doaj   +1 more source

Intracellular staining of free Dox and AS1411-Dox with Control DNA-Dox adduct.

, 2015
(a) Confocal laser scanning microscopy images displaying uptake of Dox into Huh7 cells treated with 2 μM of free Dox, AS1411-Dox adduct, or control DNA-Dox adduct, respectively.
Chen Liu (75209), Xilin Xiao (820758), Kwame Sefah (126037), Weihong Tan (9692), William Puszyk (415839), Guizhi Zhu (359782), Qunfeng Wu (820759), Thu Le Trinh (302085)   +7 more
core   +1 more source

A pH-Sensitive I-Motif Aptamer Probe for Dual Targeting and Imaging of Pancreatic Cancer Cells via Nucleolin Interactions

Journal of Bio-X Research
This study investigates the targeted imaging and tumor inhibition effects of a “signal-off” imaging-based activatable aptamer probe (I-AAP) for pancreatic cancer.
Quwen Li, Qingquan Chen, Juan Tang, Qicai Liu, Feng Gao   +4 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Abstract 3647: Gene expression analysis in AML cell line MV4-11 following treatment with the anti-cancer aptamer AS1411

, 2010
AS1411 is a 26-base DNA aptamer which is shortly due to enter a phase IIb clinical trial in acute myeloid leukaemia (AML). In an initial phase II trial in AML, combination of AS1411 with cytarabine produced an increased response rate compared to ...
David Jones, Fiona McLaughlin, Alfred Ajami, Shai Senderovich, Ben Doran   +4 more
core   +1 more source