Results 91 to 100 of about 2,544 (153)

Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release

Journal of Translational Medicine
Background Triple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with paclitaxel and fluorouracil in a sequential manner has shown promising outcomes.
Yuan Ma, Duoli Xie, Zefeng Chen, Xinyang Shen, Xiaoqiu Wu, Feng Ding, Shijian Ding, Yufei Pan, Fangfei Li, Aiping Lu, Ge Zhang   +10 more
doaj   +1 more source

Aptamer-Conjugated Au Nanocage/SiO₂ Core–Shell Bifunctional Nanoprobes with High Stability and Biocompatibility for Cellular SERS Imaging and Near-Infrared Photothermal Therapy

, 2019
The combination of surface-enhanced Raman scattering (SERS) imaging technology with near-infrared (NIR) light-triggered photothermal therapy is of utmost importance to develop novel theranostic platforms.
Xuran Miao (6240962), Tingting Xu (307597), Chenxin Cai (1473022), Jun-Jie Zhu (1329426), Li-Ping Jiang (270194), Gao-Chao Fan (1508806), Ping Wu (46628), Shengping Wen (6240959)   +7 more
core   +1 more source

Abstract 2614: Anti-tumor efficacy and pharmacokinetics of the novel aptamer AS1411 in a continuous infusion nude rat xenograft model

, 2010
AS1411 is a novel DNA aptamer that binds to the multi-functional protein nucleolin and induces cell death. AS1411 has shown activity at two different doses in combination with cytarabine in a phase II study of patients with AML.
Hakim Djeha, Fiona McLaughlin, Colin Green, Michael Bestwick, Donna Dobinson   +4 more
core   +1 more source

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Journal of Nanobiotechnology
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation ...
Miaomiao Zhang, Xinyue Lu, Lifu Luo, Jinqiu Dou, Jingbo Zhang, Ge Li, Li Zhao, Fengying Sun   +7 more
doaj   +1 more source

A Nucleolin-Targeted Multimodal Nanoparticle Imaging Probe for Tracking Cancer Cells Using an Aptamer

, 2018
The recent advances in molecular imaging techniques, using cancer-targeting nanoparticle probes, provide noninvasive tracking information on cancer cells in living subjects.
Kang, H, Ko, HY, Kim, S, Lee, JH, Ryu, SH, Song, IC, Lee, DS, Hwang, DW   +7 more
core   +1 more source

As1411-modified liposomes to enhance drug utilization and augment the anti-tumor efficacy

Cancer Nanotechnology
Background The utilization of liposomes in drug delivery has garnered significant attention due to their efficient drug loading capacity and excellent biocompatibility, rendering them a promising platform for tumor therapy.
Danhuan Zhang, Lingyun Chen, Yang Zhao, Hao Ni, Qiuying Quan, Jun Ma, Lingchuan Guo   +6 more
doaj   +1 more source

Improved anticancer efficiency of Mitoxantrone by Curcumin loaded PLGA nanoparticles targeted with AS1411 aptamer

, 2021
Objective(s): Mitoxantrone (MTX) is one of the most commonly used chemotherapeutic agents for treatment of different cancers. However, prolonged treatment with MTX results in unwanted side effects and drug resistant cancer cells.
Haghgoo, Z., Shahgordi, S., Hashemi, M., Yazdian-Robati, R., Abnous, K., Salmasi, Z.   +5 more
core  

Correction: Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer

<jats:p>Correction for ‘Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer’ by Yuejie Zhu <jats:italic>et al.</jats:italic>, <jats:italic>RSC Med.
Xu, Bo, Zhang, Qi, Sun, Xudong, Yuan, Xia, Yang, Zhenjun, Zhu, Yuejie, Ma, Yuan, Li, Xiang, Pan, Yi, Yang, Xiantao   +9 more
core   +1 more source

ATP-Responsive Aptamer-Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs

, 2017
Nanoparticles consisting of metal–organic frameworks (NMOFs) modified with nucleic acid binding strands are synthesized. The NMOFs are loaded with a fluorescent agent or with the anticancer drug doxorubicin, and the loaded NMOFs are capped by ...
Yu X., Willner I., Sohn YS, Cecconello A, Cecconello A., Liao W. -C., Kozell A, Nechushtai R, Liao WC, Sohn Y. S., Willner I, Nechushtai R., Chen WH, Chen W. -H., Kozell A., Yu X   +15 more
core   +1 more source

Preparation of Bmi-1-siRNA Lipid Nanoparticles and Effects in Gastric Cancer

Nano Biomedicine and Engineering
Malignant tumors remain a serious threat to human health and life and are a major public health problem globally. Herein, we designed and synthesized a novel nucleic acid nanomedicine AS1411-siRNA-LNPs (As@LNPs).
Hongzhang Yan, Hong Shen, Jinrong SiTu, Yingying Yang, Lingle Zhang, Kai Yang   +5 more
doaj   +1 more source