Results 41 to 50 of about 2,325 (152)

Dual-Mechanism Aptamer–Drug Complex Overcomes Paclitaxel Resistance in Ovarian Cancer via Structural Constraint and Telomerase Inhibition

Research
Paclitaxel resistance and poor tumor selectivity remain significant challenges in epithelial ovarian cancer therapy. To overcome these challenges, we engineered PSaA360, a structurally constrained aptamer–drug conjugate with a dual-functional molecular ...
Yuan Ma, Zefeng Chen, Xinyang Shen, Feng Ding, Nan Liu, Sifan Yu, Jia-Ke Xu, Hu Li, Aiping Lu, Huarui Zhang, Chuanxin Zhong, Yihao Zhang, Fangfei Li, Dong-Hua Yang, Tao Tang, Bao-Ting Zhang, Ge Zhang   +16 more
doaj   +1 more source

Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer

Turkish Journal of Analytical Chemistry, 2022
Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana ve en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara neden olabilir.
Esra BAĞDA, Rümeysa DURAK, Efkan BAĞDA, Didem DUMAN, Ebubekir AYHAN   +4 more
openaire   +6 more sources

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Rapid detection of tumor cells in serous effusion by multivalent aptamers based on rolling circle amplification

Di-san junyi daxue xuebao, 2020
Objective To establish a simple and rapid method for detecting tumor cells based on multivalent aptamers. Methods Rolling circle amplification was used to form a long single stranded DNA scaffold with repeat sequences of poly T, then the obtained product
XU Jieru, CHEN Jialing, WAN Tao, DENG Hongli, LI Dairong   +4 more
doaj   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Dual‐Drug‐Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha, Rohan Chand Sahu, Rohit Patil, Dinesh Kumar, Ashish Kumar Agrawal   +4 more
wiley   +1 more source

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells [PDF]

Molecular Pharmacology, 2009
AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute myeloid leukemia and for renal cell carcinoma. AS1411 binds to nucleolin, a protein that is overexpressed in the cytoplasm and on the plasma membrane of some tumor cells compared with normal cells.
Sridharan, Soundararajan, Li, Wang, Vijayalakshmi, Sridharan, Weiwei, Chen, Nigel, Courtenay-Luck, David, Jones, Eleanor K, Spicer, Daniel J, Fernandes   +7 more
openaire   +2 more sources

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer

Journal of Nanobiotechnology
Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens.
Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He   +4 more
doaj   +1 more source