Results 21 to 30 of about 400,682 (245)

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages

Frontiers in Immunology, 2021
Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang, Xueyue Zheng, Bingnan Liu, Yaoyao Xia, Zhongquan Xin, Baichuan Deng, Liuqin He, Liuqin He, Jinping Deng, Wenkai Ren   +9 more
doaj   +1 more source

Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women

Metabolites
Older adults sit during most hours of the day; more than 30% are considered physically inactive. The accumulation of prolonged sitting time is an exercise-independent risk factor for aging-related conditions such as cardiometabolic disease and cancer ...
Jeffrey S. Patterson, Brinda K. Rana, Haiwei Gu, Dorothy D. Sears   +3 more
doaj   +1 more source

Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis [PDF]

Proceedings of the National Academy of Sciences, 2010
D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus ...
Paul M, Kim, Xin, Duan, Alex S, Huang, Cindy Y, Liu, Guo-li, Ming, Hongjun, Song, Solomon H, Snyder   +6 more
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

Molecular Oncology, 2019
Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism via transcriptional regulation. However, direct metabolic targets of BRCA1 and the underlying regulatory mechanisms are still unknown.
Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zhan   +12 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Intrinsic organization of the corpus callosum

Frontiers in Physiology
The corpus callosum—the largest commissural fiber system connecting the two cerebral hemispheres—is considered essential for bilateral sensory integration and higher cognitive functions. Most studies exploring the corpus callosum have examined either the
Paolo Barbaresi, Mara Fabri, Teresa Lorenzi, Andrea Sagrati, Manrico Morroni   +4 more
doaj   +1 more source

Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide

Life, 2023
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite
Stuart A. Harrison, William L. Webb, Hanadi Rammu, Nick Lane   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source