Results 1 to 10 of about 181,113 (262)

Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation [PDF]

Journal of Neuroinflammation
One of the histopathological hallmarks of neuroinflammatory diseases such as multiple sclerosis (MS) is the emergence of astrocyte reactivity. Accumulating evidence suggests that excessive glycolysis may lead to astrocyte reactivity and contribute to ...
Luting Yang, Chunqing Hu, Xiaowen Chen, Mengru Sun, Jie Zhang, Zhe Feng, Tingting Cui, Ruyi Zhu, Xin Zhang, Yanxin Xiao, Ye Gong, Yang Yang, Qian Zhang, Yaling Zhang, Yaping Yan   +14 more
doaj   +2 more sources

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1 [PDF]

Cell Reports, 2018
Summary: Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and plays a critical role in brain health
Brian V. Lananna, Collin J. Nadarajah, Mariko Izumo, Michelle R. Cedeño, David D. Xiong, Julie Dimitry, Chak Foon Tso, Celia A. McKee, Percy Griffin, Patrick W. Sheehan, Jeffery A. Haspel, Ben A. Barres, Shane A. Liddelow, Joseph S. Takahashi, Ilia N. Karatsoreos, Erik S. Musiek   +15 more
doaj   +2 more sources

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets

Cells, 2022
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders and their responses to psychotropic medications are still being elucidated.
Xiaolu Zhang, Alyssa Wolfinger, Xiaojun Wu, Rawan Alnafisah, Ali Imami, Abdul-rizaq Hamoud, Anna Lundh, Vladimir Parpura, Robert E. McCullumsmith, Rammohan Shukla, Sinead M. O’Donovan   +10 more
doaj   +1 more source

Response of Astrocyte Subpopulations Following Spinal Cord Injury

Cells, 2022
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore   +9 more
doaj   +1 more source

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Molecular Neurodegeneration, 2023
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice.
Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar   +9 more
doaj   +1 more source

Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

Cell Discovery, 2023
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple lines of evidence supporting that modulation of the sleep–wake behavior by astrocyte Ca2+ activity could ...
Wanling Peng, Xiaotong Liu, Guofen Ma, Zhaofa Wu, Ziyue Wang, Xiang Fei, Meiling Qin, Lizhao Wang, Yulong Li, Siyu Zhang, Min Xu   +10 more
doaj   +1 more source

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model

Molecular Brain, 2021
The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte–neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system.
Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim, Yun Ha Jeong   +5 more
doaj   +1 more source

Dynamic image recognition in a spiking neuron network supplied by astrocytes [PDF]

, 2022
Mathematical model of spiking neuron network (SNN) supplied by astrocytes is investigated. The astrocytes are specific type of brain cells which are not electrically excitable but inducing chemical modulations of neuronal firing. We analyzed how the astrocytes influence on images encoded in the form of dynamic spiking pattern of the SNN.
arxiv   +1 more source

Glutamate mediated astrocytic filtering of neuronal activity. [PDF]

PLoS Computational Biology, 2014
Neuron-astrocyte communication is an important regulatory mechanism in various brain functions but its complexity and role are yet to be fully understood.
Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pittà, Eshel Ben Jacob, Hugues Berry, Yael Hanein   +6 more
doaj   +1 more source

Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback

Neural Plasticity, 2020
Astrocytes play a crucial role in neuronal firing activity. Their abnormal state may lead to the pathological transition of neuronal firing patterns and even induce seizures.
Yangyang Yu, Zhixuan Yuan, Yongchen Fan, Jiajia Li, Ying Wu   +4 more
doaj   +1 more source