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Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse ...
Baldwin, Katherine T +2 more
openaire +5 more sources
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the mouse central nervous system (CNS).
Fumito Endo +2 more
exaly +2 more sources
Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis [PDF]
Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the neuropil and interact with synapses. The mechanisms that control the establishment of astrocyte morphology are unknown, and it is unclear whether impairing astrocytic infiltration of the neuropil alters synaptic connectivity.
Katherine T Baldwin +2 more
exaly +3 more sources
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1 [PDF]
Summary: Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and plays a critical role in brain health
Brian V. Lananna +15 more
doaj +3 more sources
Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin +2 more
exaly +2 more sources
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy.
Adrienne A Boire +2 more
exaly +2 more sources
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
Ashley N Brandebura, Nicola J Allen
exaly +2 more sources
Astrocyte scar formation aids central nervous system axon regeneration
Mark A Anderson +2 more
exaly +2 more sources
Divergent transcriptional regulation of astrocyte reactivity across disorders
Joshua E Burda +2 more
exaly +2 more sources
Astrocyte-neuron metabolic cooperation shapes brain activity.
The brain has almost no energy reserve, but its activity coordinates organismal function, a burden that requires precise coupling between neurotransmission and energy metabolism.
G. Bonvento, J. Bolaños
semanticscholar +1 more source

