Results 1 to 10 of about 194,703 (370)

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

eLife, 2019
Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement.
Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olsen   +5 more
doaj   +2 more sources

A spatial threshold for astrocyte calcium surge [PDF]

eLife
Astrocytes are active cells involved in brain function through the bidirectional communication with neurons, in which astrocyte calcium plays a crucial role.
Justin Lines, Andres Baraibar, Carmen Nanclares, Eduardo D Martin, Juan Aguilar, Paulo Kofuji, Marta Navarrete, Alfonso Araque   +7 more
doaj   +2 more sources

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Science, 2022
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the mouse central nervous system (CNS).
F. Endo, A. Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, V. Gradinaru, R. Kawaguchi, B. Khakh   +8 more
semanticscholar   +1 more source

Response of Astrocyte Subpopulations Following Spinal Cord Injury

Cells, 2022
There is growing appreciation for astrocyte heterogeneity both across and within central nervous system (CNS) regions, as well as between intact and diseased states. Recent work identified multiple astrocyte subpopulations in mature brain. Interestingly,
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore   +9 more
doaj   +1 more source

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets

Cells, 2022
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders and their responses to psychotropic medications are still being elucidated.
Xiaolu Zhang, Alyssa Wolfinger, Xiaojun Wu, Rawan Alnafisah, Ali Imami, Abdul-rizaq Hamoud, Anna Lundh, Vladimir Parpura, Robert E. McCullumsmith, Rammohan Shukla, Sinead M. O’Donovan   +10 more
doaj   +1 more source

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Molecular Neurodegeneration, 2023
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice.
Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar   +9 more
doaj   +1 more source

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Annual Review of Neuroscience, 2022
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood flow, nutrient uptake, and waste clearance.
Blanca Díaz-Castro, S. Robel, Anusha Mishra   +2 more
semanticscholar   +1 more source

Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

Cell Discovery, 2023
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple lines of evidence supporting that modulation of the sleep–wake behavior by astrocyte Ca2+ activity could ...
Wanling Peng, Xiaotong Liu, Guofen Ma, Zhaofa Wu, Ziyue Wang, Xiang Fei, Meiling Qin, Lizhao Wang, Yulong Li, Siyu Zhang, Min Xu   +10 more
doaj   +1 more source

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model

Molecular Brain, 2021
The morphological dynamics of astrocytes are altered in the hippocampus during memory induction. Astrocyte–neuron interactions on synapses are called tripartite synapses. These control the synaptic function in the central nervous system.
Moonseok Choi, Sang-Min Lee, Dongsoo Kim, Heh-In Im, Hye-Sun Kim, Yun Ha Jeong   +5 more
doaj   +1 more source

Glutamate mediated astrocytic filtering of neuronal activity. [PDF]

PLoS Computational Biology, 2014
Neuron-astrocyte communication is an important regulatory mechanism in various brain functions but its complexity and role are yet to be fully understood.
Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pittà, Eshel Ben Jacob, Hugues Berry, Yael Hanein   +6 more
doaj   +1 more source