Nature Medicine, 2023 An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and ...
Bruna Bellaver +2 more
exaly +2 more sources
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Nature Medicine, 2018 Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases1,2.
Seung Pil Yun +2 more
exaly +2 more sources
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Nature, 2016 Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy.
Adrienne A Boire +2 more
exaly +2 more sources
Sox9 regulation of hexokinase 1 controls neuroinflammatory astrocyte subtypes in a rat model of neuropathic pain [PDF]
Nature CommunicationsNeuropathic pain, caused by nerve damage, lacks effective treatments. Astrocytes drive chronic neuroinflammation in the dorsal horn, but directly targeting them is challenging due to their heterogeneity and beneficial roles. The regulation of deleterious
Yonglong Chen +11 more
doaj +2 more sources
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1 [PDF]
Cell Reports, 2018 Summary: Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and plays a critical role in brain health
Brian V. Lananna +15 more
doaj +3 more sources
Reactive astrocyte nomenclature, definitions, and future directions
Nature Neuroscience, 2021 Carole Escartin +2 more
exaly +2 more sources
Astrocyte scar formation aids central nervous system axon regeneration
Nature, 2016 Mark A Anderson +2 more
exaly +2 more sources
Divergent transcriptional regulation of astrocyte reactivity across disorders
Nature, 2022 Joshua E Burda +2 more
exaly +2 more sources
Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake. [PDF]
PLoS BiologyClassical neuromodulators regulate arousal states, spanning deep sleep to vigilant wakefulness, primarily by activating cortical neurons. However, cortical astrocytes also express neuromodulatory G-protein-coupled receptors (GPCRs).
Charlotte R Taylor +6 more
doaj +2 more sources
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease
Science, 2022 Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the mouse central nervous system (CNS).
F. Endo +8 more
semanticscholar +1 more source