Astrocyte Reprogramming in Stroke: Opportunities and Challenges
Frontiers in Aging Neuroscience, 2022 Stroke is a major cause of morbidity and mortality worldwide. In the early stages of stroke, irreversible damage to neurons leads to high mortality and disability rates in patients.
Zhouzhou Peng +7 more
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Emergent dynamics in an astrocyte-neuronal network coupled via nitric oxide [PDF]
, 2022 In the brain, both neurons and glial cells work in conjunction with each other during information processing. Stimulation of neurons can cause calcium oscillations in astrocytes which in turn can affect neuronal calcium dynamics. The "glissandi" effect is one such phenomenon, associated with a decrease in infraslow fluctuations, in which synchronized ...
arxiv +1 more source
Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. [PDF]
, 2013 Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Binder, Devin K +3 more
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Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. [PDF]
PLoS Biology, 2012 Long-term potentiation (LTP) of synaptic transmission represents the cellular basis of learning and memory. Astrocytes have been shown to regulate synaptic transmission and plasticity.
Marta Navarrete +6 more
doaj +1 more source
FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]
, 2007 After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C. +7 more
core +2 more sources
Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes
Cells, 2019 Vimentin (VIM) is an intermediate filament (nanofilament) protein expressed in multiple cell types, including astrocytes. Mice with VIM mutations of serine sites phosphorylated during mitosis (VIMSA/SA) show cytokinetic failure in fibroblasts and lens ...
Yolanda de Pablo +6 more
doaj +1 more source
Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. [PDF]
, 2014 Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation.
Chen, Yidan +10 more
core +3 more sources
Journal of Neuroinflammation, 2023 Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology.
Jingxian Lun +10 more
doaj +1 more source
p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. [PDF]
, 2014 In CNS lesions, "reactive astrocytes" form a prominent cellular response. However, the nature of this astrocyte immune activity is not well understood.
Chechneva, OV +5 more
core +1 more source
Mechanosensory Signaling in Astrocytes [PDF]
The Journal of Neuroscience, 2020 Mechanosensitivity is a well-known feature of astrocytes, however, its underlying mechanisms and functional significance remain unclear. There is evidence that astrocytes are acutely sensitive to decreases in cerebral perfusion pressure and may function as intracranial baroreceptors, tuned to monitor brain blood flow.
Alexander V. Gourine +13 more
openaire +7 more sources