Results 51 to 60 of about 283,599 (345)

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. [PDF]

, 2019
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality.
Carromeu, Cassiano, Freitas, Beatriz CG, Ghosh, Anirvan, Hu, Xindao, Kim, Jean J, Lavallée-Adam, Mathieu, Miller, Meghan T, Muotri, Alysson R, Savas, Jeffrey N, Yates, John R   +9 more
core   +2 more sources

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

Frontiers in Pharmacology
BackgroundTumor metabolism reprogramming is a hallmark of cancer, but metabolite-mediated intercellular communication remains poorly understood. To address this gap, we estimated and explored communication events exploring based on single‐cell RNA data ...
Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang   +9 more
doaj   +1 more source

Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus. [PDF]

PLoS ONE, 2013
BACKGROUND: Besides their neuronal support functions, astrocytes are active partners in neuronal information processing. The typical territorial structure of astrocytes (the volume of neuropil occupied by a single astrocyte) is pivotal for many aspects ...
Antje Grosche, Jens Grosche, Mark Tackenberg, Dorit Scheller, Gwendolyn Gerstner, Annett Gumprecht, Thomas Pannicke, Petra G Hirrlinger, Ulrika Wilhelmsson, Kerstin Hüttmann, Wolfgang Härtig, Christian Steinhäuser, Milos Pekny, Andreas Reichenbach   +13 more
doaj   +1 more source

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

eLife, 2019
Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement.
Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olsen   +5 more
doaj   +1 more source

Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques [PDF]

, 2014
<b>Background</b><p></p> Myelination is a very complex process that requires the cross talk between various neural cell types.
Anderson, Kurt I, Barnett, Susan C, Edgar, Julia M, Ioannidou, Kalliopi, Strachan, David   +4 more
core   +2 more sources

A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation

Journal of Neuroinflammation, 2020
Interactions between neurons, astrocytes, and microglia critically influence neuroinflammatory responses to insult in the central nervous system. In vitro astrocyte and microglia cultures are powerful tools to study specific molecular pathways involved ...
Noah Goshi, Rhianna K Morgan, P. Lein, E. Şeker   +3 more
semanticscholar   +1 more source

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia

Biomedicines, 2023
Astrocyte inflammation activation is an important cause that hinders the recovery of motor function after cerebral ischemia. However, its molecular mechanism has not yet been clearly clarified.
Doudou Luo, Wenxuan Ye, Ling Chen, Xiaoqian Yuan, Yali Zhang, Caixia Chen, Xin Jin, Yu Zhou   +7 more
doaj   +1 more source

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source

A spatial threshold for astrocyte calcium surge

eLife
Astrocytes are active cells involved in brain function through the bidirectional communication with neurons, in which astrocyte calcium plays a crucial role.
Justin Lines, Andres Baraibar, Carmen Nanclares, Eduardo D Martin, Juan Aguilar, Paulo Kofuji, Marta Navarrete, Alfonso Araque   +7 more
doaj   +1 more source

UHPLC–electrospray ionization–mass spectrometric analysis of brain cell-specific glucogenic and neurotransmitter amino acid content

Scientific Reports, 2021
Astrocyte glycogen, the primary energy reserve in brain, undergoes continuous remodeling by glucose passage through the glycogen shunt prior to conversion to the oxidizable energy fuel l-lactate.
Khaggeswar Bheemanapally, Prabhat R. Napit, Mostafa M. H. Ibrahim, Karen P. Briski   +3 more
doaj   +1 more source