Results 31 to 40 of about 2,455 (178)
Molecules, 2019 Chirality is one of the most important attributes for its presence in a vast majority of bioactive natural products and pharmaceuticals. Asymmetric organocatalysis methods have emerged as a powerful methodology for the construction of highly ...
Zhonglei Wang
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Design, synthesis, and evaluation of chiral thiophosphorus acids as organocatalysts
Beilstein Journal of Organic Chemistry, 2022 A series of P-stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. In order to eliminate the need for C2-symmetry in common CPAs, various scaffolds containing C1-symmetrical ...
Karen R. Winters, Jean-Luc Montchamp
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On the Nature of Improper Hydrogen Bonding in RCH2F and RCHF2 Motifs
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.The nature of ‘improper’ hydrogen bonds is explored in FnC─H⋯X systems, such as RCF2H interaction with chloride and water. It is noted that increased fluorination decreases the positive charge density on H but increases it on C, thus these interactions are dominated by electrostatic attraction to C over H.
Bruno A. Piscelli +3 more
wiley +2 more sources
Recent Advances in Asymmetric Organocatalyzed Conjugate Additions to Nitroalkenes
Molecules, 2017 The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks.
Diego A. Alonso +6 more
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Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
Green Synthesis and Catalysis, 2020 Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers.
Haifeng Wang +4 more
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Asymmetric reactions of N-heterocyclic carbene (NHC)-based chiral acyl azoliums and azolium enolates
Green Synthesis and Catalysis, 2021 N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful synthetic strategy for the construction of a wide variety of medicinally and biologically important molecules.
Changgui Zhao +2 more
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Elucidating Ligand‐Dependent Selectivities in Pd‐Catalyzed C–H Activations
Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.Strategies to understand ligand effects on regioselectivities of C–H activation processes were investigated using an alkynylation of thiophenes as a model system. The results shed light on the role of dispersion models for the correct prediction of reaction outcomes and propose new roles for the solvent and silver additive.
Fritz Deufel +2 more
wiley +2 more sources
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
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Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances
Molecules, 2017 The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities ...
Tecla Gasperi +3 more
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