Results 231 to 240 of about 2,749,588 (276)
Some of the next articles are maybe not open access.
ATP-Sensitive Potassium Channels
Current Pharmaceutical Design, 2005ATP-sensitive potassium (K(ATP)) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and by other factors including membrane phospholipids, protein kinases and phosphatases. K(ATP) channels comprise octamers of four Kir6 pore-forming subunits associated with four sulphonylurea receptor subunits.
Rodrigo, GC, Standen, NB
openaire +3 more sources
ATP-Sensitive Potassium Channels: A Review of their Cardioprotective Pharmacology
Journal of Molecular and Cellular Cardiology, 2000ATP-sensitive potassium channels (K(ATP)) have been thought to be a mediator of cardioprotection for the last ten years. Significant progress has been made in learning the pharmacology of this channel as well as its molecular regulation with regard to cardioprotection.
Keith D Garlid, Gary J Grover
exaly +3 more sources
The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels
Molecular Pharmacology, 2022ATP-sensitive potassium channels (KATP) are energy sensors that participate in a range of physiologic processes. These channels are also clinically validated drug targets. For decades, KATP inhibitors have been prescribed for diabetes and KATP activators have been used for the treatment of hypoglycemia, hypertension, and hair loss.
Jing-Xiang Wu, Dian Ding, Lei Chen
openaire +2 more sources
Regulation of the ATP-Sensitive Potassium Channel
1990A new class of K+ channels that link membrane potential to the bioenergetic situation of the cell has recently been discovered. These K+ channels (KATP) are normally closed at physiological intracellular ATP concentrations and open upon a diminution of [ATP]in.
J R, de Weille, M, Lazdunski
openaire +2 more sources
ATP-Sensitive Potassium Channels in Health and Disease
2010The ATP-sensitive potassium (K(ATP)) channel plays a crucial role in insulin secretion and thus glucose homeostasis. K(ATP) channel activity in the pancreatic beta-cell is finely balanced; increased activity prevents insulin secretion, whereas reduced activity stimulates insulin release. The beta-cell metabolism tightly regulates K(ATP) channel gating,
Proks, P, Clarke, R
openaire +3 more sources
ATP-Sensitive Potassium Channels
Journal of Cardiovascular Pharmacology, 1994ATP-sensitive potassium channels are found in a number of different tissues where they undertake distinct physiologic functions. In endocrine cells they regulate the secretion of hormones such as insulin, prolactin, and growth hormone. They influence the excitability of cardiac, skeletal, and vascular smooth muscle.
openaire +2 more sources
ATP-sensitive potassium channels are not expressed in brain microvessels
Brain Research, 1993We used [3H]glibenclamide binding to assess ATP-sensitive K+ channels in isolated cerebral microvessels and in the cerebral cortex of the rat. We found no measurable specific glibenclamide binding in cerebral microvessels despite its abundance in cerebral cortical membranes, implying that ATP-sensitive K+ channels are not present in cerebral ...
H C, Sullivan, S I, Harik
openaire +2 more sources
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
The Lancet, 1985The stimulation of insulin secretion from the beta cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability. Tolbutamide reduced K+ movement through an ATP-sensitive K+ channel in patches of plasma membrane from an insulin-producing cell line when applied to the external surface of the ...
Sturgess, Nicholas C. +3 more
openaire +3 more sources
ATP-sensitive potassium channels in cultured arterial segments
American Journal of Physiology-Heart and Circulatory Physiology, 1996Organ cultures of arteries have been used to study growth responses, proliferation, and contractility. However, the function of specific-ion channels in cultured arteries has not been investigated. ATP-sensitive K+ (KATP) channels play an important role in the control of arterial tone.
Kleppisch, Thomas +2 more
openaire +3 more sources
Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection
Archives of Biochemistry and Biophysics, 2003ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in the myocardium with one subtype located in the sarcolemma membrane and the other in the inner membrane of the mitochondria. The ATP-sensitive potassium channels can be pharmacologically modulated by a family
James D McCully, Sidney Levitsky
exaly +3 more sources