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Dual regulation of the ATP-sensitive potassium channel by caffeine
American Journal of Physiology-Cell Physiology, 2007ATP-sensitive potassium (KATP) channels couple cellular metabolic status to changes in membrane electrical properties. Caffeine (1,2,7-trimethylxanthine) has been shown to inhibit several ion channels; however, how caffeine regulates KATPchannels was not well understood.
Xia, Mao, Yongping, Chai, Yu-Fung, Lin
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ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Comprehensive Physiology, 2018ABSTRACT ATP sensitive potassium channels (K ATP ) are so named because they open as cellular ATP levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to membrane excitability.
Tinker, A, Aziz, Q, Li, Y, Specterman, M
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ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update [PDF]
Current Pharmaceutical Design, 2014 Ischemia and heart failure-related cardiac arrhythmias, both atrial (e.g., atrial fibrillation) and ventricular (e.g., malignant tachyarrhythmias) represent a leading cause of morbidity and mortality worldwide. Despite the progress made in the last decade in understanding their pathophysiological mechanisms there is still an unmet need for safer and ...
Muntean, Danina +3 more
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ATP-sensitive potassium channels and myocardial preconditioning
Basic Research in Cardiology, 1995The ATP-sensitive potassium channel (KATP) has been shown to serve an endogenous cardioprotective role in a number of experimental models of myocardial stunning and infarction. More importantly, a majority of evidence has also been obtained which suggests that the KATP channel may be intimately involved in both triggering and maintaining the ...
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Trafficking of ATP-sensitive potassium channels in health and disease
Biochemical Society Transactions, 2007KATP channels (ATP-sensitive potassium channels), comprising four subunits each of Kir6.2 (inwardly rectifying potassium channel 6.2) and the SUR1 (sulfonylurea receptor 1), play a central role in glucose-stimulated insulin secretion by the pancreatic β-cell.
Sivaprasadarao, A. +3 more
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ATP-sensitive potassium channels: metabolic sensing and cardioprotection
Journal of Applied Physiology, 2007The cardiovascular system operates under a wide scale of demands, ranging from conditions of rest to extreme stress. How the heart muscle matches rates of ATP production with utilization is an area of active investigation. ATP-sensitive potassium (KATP) channels serve a critical role in the orchestration of myocardial energetic well-being.
L V, Zingman +3 more
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ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies
Annual Review of Physiology, 1999▪ Abstract ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular ...
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Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine
Anesthesiology, 1997Background The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel underlies the increase in potassium permeability during hypoxia and ischemia. The increased outward potassium current during ischemia may be an endogenous cardioprotective mechanism.
S H, Ko +7 more
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ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology
Current Opinion in Nephrology and Hypertension, 1992Potassium-selective ion channels, whose activity is inhibited by micromolar to millimolar concentrations of ATP presented at the cytoplasmic ATP-sensitive K+ (K+[ATP]) surface, have been found in a variety of cell types. These "K+(ATP) channels" have emerged as significant targets for physiologic as well as pharmacologic modulation of cell processes ...
S, Misler, G, Giebisch
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Amiodarone Inhibits Cardiac ATP‐Sensitive Potassium Channels
Journal of Cardiovascular Electrophysiology, 2000Amiodarone Inhibition of Cardiac KATPChannels.Introdttction:ATP‐sensitive K+channels (KATP) are expressed abundantly in cardiovascular tissues. Blocking this channel in experinuntal models of ischemia can reduce arrhythmias. We investigated the acute effects of amiodarone on the activity of cardiac sarcolemmal KATPchannels and their sensitivity to ATP ...
D S, Holmes +6 more
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