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Involvement of ATP-sensitive potassium channels in preconditioning protection

Basic Research in Cardiology, 1994
Single or multiple brief periods of ischemia (preconditioning, PC) have been shown to protect the myocardium from infarction during a subsequent more prolonged ischemic insult. To test the hypothesis that opening of ATP-sensitive potassium channels (KATP) is involved in this mechanism, either bimakalim, a KATP channel opener, or glibenclamide, a KATP ...
S, Rohmann   +5 more
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The Role of ATP Sensitive Potassium Channels in Myocardial Protection

Journal of Cardiac Surgery, 1995
Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A1-receptor agonists.
B A, Cason   +3 more
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Modulation of ischemia by regulation of the ATP-sensitive potassium channel

Cardiovascular Drugs and Therapy, 1993
During acute myocardial ischemia, passage of potassium ions across the sarcolemma to the extracellular space is a well-established phenomenon. A recent hypothesis is that the ATP-dependent potassium channel plays a role in contributing to the potassium loss.
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Properties of cardiac ATP-sensitive potassium channels

1996
It has long been known that the cardiac action potential shortens during ischemia or hypoxia and that this shortening results primarily from an increased potassium conductance [1]. About ten years ago, Hiroshi Irisawa and colleagues [2] showed that the K+ conductance increase, and action potential shortening, can be reversed by injecting ATP into ...
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Regulation of ATP-sensitive potassium channels by phosphorylation

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1996
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[23] ATP-Sensitive potassium channels

1999
M. Schwanstecher   +7 more
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