Results 11 to 20 of about 33,070 (201)

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

Shock, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +5 more sources

Atypical chemokine receptor 4 shapes activated B cell fate [PDF]

Journal of Experimental Medicine, 2018
Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed, Babb, Rachelle, Bastow, Cameron R., Bourne, Katherine, Brink, Robert, Comerford, Iain, Cyster, Jason G., Fenix, Kevin A., Gilchrist, Derek S., Gregor, Carly E., Hermes, Jana R., Hill, Geoffrey R., Kara, Ervin E., McColl, Shaun R., McKenzie, Duncan R., Nibbs, Robert J., Norton, Todd S., Rodda, Lauren B., Tarlinton, David M., Vinuesa, Carola G., Zotos, Dimitra   +20 more
core   +9 more sources

Corrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology. [PDF]

Front Immunol, 2017
Bonavita O, Mollica Poeta V, Setten E, Massara M, Bonecchi R.   +4 more
europepmc   +4 more sources

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. [PDF]

Nat Commun, 2020
Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Meyrath M, Szpakowska M, Zeiner J, Massotte L, Merz MP, Benkel T, Simon K, Ohnmacht J, Turner JD, Krüger R, Seutin V, Ollert M, Kostenis E, Chevigné A.   +13 more
europepmc   +2 more sources

CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12. [PDF]

PLoS ONE, 2014
Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3).
Rita de Cássia Carvalho Melo, Ana Leda Longhini, Carolina Louzão Bigarella, Mariana Ozello Baratti, Fabiola Traina, Patrícia Favaro, Paula de Melo Campos, Sara Teresinha Olalla Saad   +7 more
doaj   +4 more sources

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. [PDF]

Nat Commun, 2020
The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3 ...
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P.   +15 more
europepmc   +2 more sources

Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia. [PDF]

Sci Rep
Lack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltrate the tumor microenvironment.
Benoit A, Lequeux A, Harter P, Berchem G, Janji B.   +4 more
europepmc   +2 more sources

Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. [PDF]

PLoS Genetics, 2011
Chromosome 3p21-22 harbors two clusters of chemokine receptor genes, several of which serve as major or minor coreceptors of HIV-1. Although the genetic association of CCR5 and CCR2 variants with HIV-1 pathogenesis is well known, the role of variation in
Ping An, Rongling Li, Ji Ming Wang, Teizo Yoshimura, Munehisa Takahashi, Ram Samudralal, Stephen J O'Brien, John Phair, James J Goedert, Gregory D Kirk, Jennifer L Troyer, Efe Sezgin, Susan P Buchbinder, Sharyne Donfield, George W Nelson, Cheryl A Winkler   +15 more
doaj   +6 more sources

Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2. [PDF]

Vaccines (Basel), 2020
The atypical chemokine receptor ACKR2, formerly named D6, is a scavenger chemokine receptor with a non-redundant role in the control of inflammation and immunity. The scavenging activity of ACKR2 depends on its trafficking properties, which require actin
Vacchini A, Cancellieri C, Milanesi S, Badanai S, Savino B, Bifari F, Locati M, Bonecchi R, Borroni EM.   +8 more
europepmc   +2 more sources

Structural basis of ligand interaction with atypical chemokine receptor 3 [PDF]

Nature Communications, 2017
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ...
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel   +10 more
doaj   +5 more sources